Human sperm associated antigen 4 (SPAG4) is a potential cancer marker

被引：39
作者：
Kennedy, C
Sebire, K
de Kretser, DM
O'Bryan, MK
机构：
[1] Monash Univ, Monash Inst Reprod & Dev, Clayton, Vic 3168, Australia
[2] Monash Univ, Monash Inst Reprod & Dev, Melbourne, Vic 3168, Australia
[3] Monash Univ, ARC Ctr Excellence Biotechnol & Dev, Melbourne, Vic 3168, Australia
来源：
CELL AND TISSUE RESEARCH | 2004年 / 315卷 / 02期
基金：
英国医学研究理事会;
关键词：
antigen; cancer; immunotherapy; sperm; testis; human;
D O I：
10.1007/s00441-003-0821-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4. SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23. It is expressed in a limited number of normal tissues, notably the pancreas and testis, but is switched on and greatly upregulated in a wide range of neoplastic tissues. The data therefore strongly suggests that SPAG4 expression is a potential clinically relevant cancer marker.
引用
收藏
页码：279 / 283
页数：5
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