Azadirachta indica leaf extract mediated biosynthesized rod-shaped zinc oxide nanoparticles for in vitro lung cancer treatment

被引：8
作者：
Rani, Nutan [1 ]
Rawat, Kavita [2 ]
Saini, Mona [1 ]
Yadav, Sapna [1 ]
Shrivastava, Anju [2 ]
Saini, Kalawati [1 ]
Maity, Dipak [3 ,4 ]
机构：
[1] Univ Delhi, Dept Chem, Miranda House,Patel Chest Marg, New Delhi 110007, India
[2] Univ Delhi, Dept Zool, North Campus, New Delhi 110007, India
[3] Univ Petr & Energy Studies, Dept Chem Engn, Dehra Dun 248007, Uttarakhand, India
[4] Univ Petr & Energy Studies, Sch Hlth Sci & Technol, Dehra Dun 248007, Uttarakhand, India
来源：
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS | 2022年 / 284卷
关键词：
Azadirachta indica; Zinc oxide nanoparticles; Apoptosis; Lung cancer treatment; Biosynthesis using Neem leaf extract; GREEN SYNTHESIS; ZNO NANOPARTICLES; ANTIBACTERIAL; ANTICANCER;
D O I：
10.1016/j.mseb.2022.115851
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this work, ZnO nanoparticles (NPs - L5 and L10) are biosynthesized using 5 mL and 10 mL leaf extract of Azadirachta indica, respectively. As-prepared L5/L10 NPs revealed hexagonal wurtzite structure while their surface is attached with phytochemicals coating. FESEM micrographs confirmed 50 - 120 and 30 - 70 nm rod-shaped L5/L10 ZnO nanoparticles. DLS study showed hydrodynamic sizes 580.41/356.2 nm and zeta potential values of -47.17/ 51.70 mV for L5/L10, respectively indicating their good colloidal stability. The anticancer activity of L5/L10 NPs is evaluated via MTT assay which confirmed that the cell viability of A549 cells is significantly reduced depending on the dosage of L5/L10 NPs. Moreover, IC50 values are obtained as 125.64 and 115.63 mu g/mL for L5 and L10, respectively. Furthermore, flow cytometry reveals 88 % and 89.3 % arrest of the G1 phase of the cell cycle due to the anticancer effect of L5 and L10 NPs, respectively.
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页数：10
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