New insights into the mechanisms of diastolic dysfunction in patients with type 2 diabetes

被引:4
作者
Bayraktar, Ali [1 ]
Canpolat, Ugur [2 ]
Demiri, Edis [3 ]
Kunak, Aysegul Ulgen [4 ]
Ozer, Necla [3 ]
Aksoyek, Serdar [3 ]
Ovunc, Kenan [3 ]
Ozkan, Adem [5 ]
Yildiz, Okan Bulent [6 ]
Atalar, Enver [3 ]
机构
[1] Ahi Evren Cardiovasc & Thorac Surg Training & Res, Cardiol Clin, Trabzon, Turkey
[2] Turkiye Yuksek Ihtisas Training & Res Hosp, Cardiol Clin, Ankara, Turkey
[3] Hacettepe Univ, Dept Cardiol, Ankara, Turkey
[4] Kayseri Training & Res Hosp, Cardiol Clin, Kayseri, Turkey
[5] Hacettepe Univ, Dept Biochem, Ankara, Turkey
[6] Hacettepe Univ, Dept Endocrinol & Metab Dis, Ankara, Turkey
关键词
diastolic dysfunction; sRAGE; type; 2; diabetes; GLYCATION END-PRODUCTS; ENDOGENOUS SECRETORY RAGE; STANDARDS COMMITTEE; RECEPTOR; RECOMMENDATIONS; ECHOCARDIOGRAPHY; QUANTIFICATION; PREVALENCE; EXPRESSION; PREVENTS;
D O I
10.3109/14017431.2015.1039571
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Little is known about the role of advanced glycation end products (AGEs) and their receptor (RAGE) in diabetic cardiovascular complications. Therefore, we aimed to evaluate the association of serum soluble RAGE (sRAGE) levels and left ventricular (LV) diastolic dysfunction in patients with type 2 diabetes. Methods. Our study consisted of 40 patients with type 2 diabetes and 40 age-and sex-matched healthy control group. Subjects with age >= 50 years old and any cardiovascular risk factors or conditions were excluded from the study. Serum sRAGE levels determined by enzyme-linked immunosorbent assay and LV diastolic dysfunction were evaluated according to current American Society of Echocardiography guidelines. Results. Baseline characteristics were similar between groups except body mass index, waist-hip ratio, and fasting glucose levels. Serum sRAGE level was significantly lower in diabetic group compared with control group (676 +/- 128 vs. 1044 +/- 344, p < 0.05). Diastolic dysfunction was observed in 50% of diabetic patients (40% grade I and 10% grade II). Correlation analysis showed that serum sRAGE was negatively correlated with duration of diabetes, septal E'/A', lateral E'/A', and average E/E'. In multivariate regression analysis, serum sRAGE level was strongly associated with diastolic dysfunction in patients with type 2 diabetes. Conclusion. Our study showed that serum sRAGE level was significantly lower in type 2 diabetic patients aged <50 years old. Also, sRAGE has negative correlation with the duration of diabetes and it was significantly associated with the presence of diastolic dysfunction in type 2 diabetes.
引用
收藏
页码:142 / 148
页数:7
相关论文
共 28 条
  • [1] Diabetic cardiomyopathy
    Asghar, Omar
    Al-Sunni, Ahmed
    Khavandi, Kaivan
    Khavandi, Ali
    Withers, Sarah
    Greenstein, Adam
    Heagerty, Anthony M.
    Malik, Rayaz A.
    [J]. CLINICAL SCIENCE, 2009, 116 (9-10) : 741 - 760
  • [2] Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein
    Basta, Giuseppina
    Sironi, Anna Maria
    Lazzerini, Guido
    Del Turco, Serena
    Buzzigoli, Emma
    Casolaro, Arturo
    Natali, Andrea
    Ferrannini, Ele
    Gastaldelli, Amalia
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (11) : 4628 - 4634
  • [3] Advanced glycation end products: role in pathology of diabetic cardiomyopathy
    Bodiga, Vijaya Lakshmi
    Eda, Sasidhar Reddy
    Bodiga, Sreedhar
    [J]. HEART FAILURE REVIEWS, 2014, 19 (01) : 49 - 63
  • [4] Diabetic cardiomyopathy revisited
    Boudina, Sihem
    Abel, E. Dale
    [J]. CIRCULATION, 2007, 115 (25) : 3213 - 3223
  • [5] Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus
    Boyer, JK
    Thanigaraj, S
    Schechtman, KB
    Pérez, JE
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (07) : 870 - 875
  • [6] RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice
    Bucciarelli, LG
    Wendt, T
    Qu, W
    Lu, Y
    Lalla, E
    Rong, LL
    Goova, MT
    Moser, B
    Kislinger, T
    Lee, DC
    Kashyap, Y
    Stern, DM
    Schmidt, AM
    [J]. CIRCULATION, 2002, 106 (22) : 2827 - 2835
  • [7] Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease
    Cooper, ME
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2004, 17 (12) : 31S - 38S
  • [8] Determinants of reduction of coronary flow reserve in patients with type 2 diabetes mellitus or arterial hypertension without angiographically determined epicardial coronary stenosis
    Galderisi, Maurizio
    Capaldo, Brunella
    Sidiropulos, Milena
    D'Errico, Arcangelo
    Ferrara, Luigi
    Turco, Annamelia
    Guarini, Pasquale
    Riccardi, Gabriele
    de Divitiis, Oreste
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2007, 20 (12) : 1283 - 1290
  • [9] AGE/RAGE produces endothelial dysfunction in coronary arterioles in Type 2 diabetic mice
    Gao, Xue
    Zhang, Hanrui
    Schmidt, Ann Marie
    Zhang, Cuihua
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 295 (02): : H491 - H498
  • [10] Serum endogenous secretory RAGE levels are inversely associated with carotid IMT in type 2 diabetic patients
    Katakami, Naoto
    Matsuhisa, Munehide
    Kaneto, Hideaki
    Yamasaki, Yoshimitsu
    [J]. ATHEROSCLEROSIS, 2007, 190 (01) : 22 - 23