Background. Little is known about the role of advanced glycation end products (AGEs) and their receptor (RAGE) in diabetic cardiovascular complications. Therefore, we aimed to evaluate the association of serum soluble RAGE (sRAGE) levels and left ventricular (LV) diastolic dysfunction in patients with type 2 diabetes. Methods. Our study consisted of 40 patients with type 2 diabetes and 40 age-and sex-matched healthy control group. Subjects with age >= 50 years old and any cardiovascular risk factors or conditions were excluded from the study. Serum sRAGE levels determined by enzyme-linked immunosorbent assay and LV diastolic dysfunction were evaluated according to current American Society of Echocardiography guidelines. Results. Baseline characteristics were similar between groups except body mass index, waist-hip ratio, and fasting glucose levels. Serum sRAGE level was significantly lower in diabetic group compared with control group (676 +/- 128 vs. 1044 +/- 344, p < 0.05). Diastolic dysfunction was observed in 50% of diabetic patients (40% grade I and 10% grade II). Correlation analysis showed that serum sRAGE was negatively correlated with duration of diabetes, septal E'/A', lateral E'/A', and average E/E'. In multivariate regression analysis, serum sRAGE level was strongly associated with diastolic dysfunction in patients with type 2 diabetes. Conclusion. Our study showed that serum sRAGE level was significantly lower in type 2 diabetic patients aged <50 years old. Also, sRAGE has negative correlation with the duration of diabetes and it was significantly associated with the presence of diastolic dysfunction in type 2 diabetes.
机构:
Manchester Royal Infirm, Manchester Heart Ctr, Manchester M13 9WL, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Asghar, Omar
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Al-Sunni, Ahmed
Khavandi, Kaivan
论文数: 0引用数: 0
h-index: 0
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Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Khavandi, Kaivan
Khavandi, Ali
论文数: 0引用数: 0
h-index: 0
机构:
Bristol Royal Infirm & Gen Hosp, Bristol Heart Inst, Bristol BS1 3NU, Avon, England
Univ Bristol, Bristol BS1 3NU, Avon, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Khavandi, Ali
Withers, Sarah
论文数: 0引用数: 0
h-index: 0
机构:
Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Withers, Sarah
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机构:
Greenstein, Adam
Heagerty, Anthony M.
论文数: 0引用数: 0
h-index: 0
机构:
Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Heagerty, Anthony M.
Malik, Rayaz A.
论文数: 0引用数: 0
h-index: 0
机构:
Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
机构:
Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USA
Boudina, Sihem
Abel, E. Dale
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USA
机构:
Univ Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Med Pharmacol & Physiol, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Nutr Sci, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Gao, Xue
Zhang, Hanrui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Med Pharmacol & Physiol, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Nutr Sci, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Zhang, Hanrui
Schmidt, Ann Marie
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Surg, New York, NY USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Schmidt, Ann Marie
Zhang, Cuihua
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Med Pharmacol & Physiol, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Nutr Sci, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Zhang, Cuihua
[J].
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,
2008,
295
(02):
: H491
-
H498
机构:
Manchester Royal Infirm, Manchester Heart Ctr, Manchester M13 9WL, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Asghar, Omar
论文数: 引用数:
h-index:
机构:
Al-Sunni, Ahmed
Khavandi, Kaivan
论文数: 0引用数: 0
h-index: 0
机构:
Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Khavandi, Kaivan
Khavandi, Ali
论文数: 0引用数: 0
h-index: 0
机构:
Bristol Royal Infirm & Gen Hosp, Bristol Heart Inst, Bristol BS1 3NU, Avon, England
Univ Bristol, Bristol BS1 3NU, Avon, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Khavandi, Ali
Withers, Sarah
论文数: 0引用数: 0
h-index: 0
机构:
Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Withers, Sarah
论文数: 引用数:
h-index:
机构:
Greenstein, Adam
Heagerty, Anthony M.
论文数: 0引用数: 0
h-index: 0
机构:
Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Heagerty, Anthony M.
Malik, Rayaz A.
论文数: 0引用数: 0
h-index: 0
机构:
Manchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
Univ Manchester, Manchester M13 9NT, Lancs, EnglandManchester Royal Infirm, Dept Med, Cardiovasc Res Grp, Manchester M13 9NT, Lancs, England
机构:
Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USA
Boudina, Sihem
Abel, E. Dale
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USA
机构:
Univ Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Med Pharmacol & Physiol, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Nutr Sci, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Gao, Xue
Zhang, Hanrui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Med Pharmacol & Physiol, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Nutr Sci, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Zhang, Hanrui
Schmidt, Ann Marie
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Coll Phys & Surg, Dept Surg, New York, NY USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Schmidt, Ann Marie
Zhang, Cuihua
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Med Pharmacol & Physiol, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Univ Missouri, Dept Nutr Sci, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USAUniv Missouri, Dept Internal Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA
Zhang, Cuihua
[J].
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,
2008,
295
(02):
: H491
-
H498