Optimal delivery of chemotherapeutic agents in cancer

被引:63
|
作者
Dua, Pinky [1 ]
Dua, Vivek [2 ]
Pistikopoulos, Efstratios N. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Ctr Proc Syst Engn, Dept Chem Engn, London SW7 2AZ, England
[2] UCL, Ctr Proc Syst Engn, Dept Chem Engn, London WC1E 7JE, England
关键词
drug delivery systems; cancer; chemotherapy; optimal control; mixed integer dynamic optimization;
D O I
10.1016/j.compchemeng.2007.07.001
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
Cancer refers to a set of diseases where normal cells of the body lose mechanisms which are responsible for controlling their growth and motility. Chemotherapy aims to kill these abnormal or cancer cells, however normal cells and healthy tissues are also adversely affected. Systematic modelling and optimization approaches can be employed to obtain effective chemotherapeutic protocol that minimizes the tumour cell population while limiting the damage to the normal cells. In this paper, two models for cancer chemotherapy are considered and the effect of the time of drug administration on the final tumour size is analyzed. The first model is cell cycle non-specific and considers all the cancer cells as belonging to one compartment whereas the second model is cell cycle specific and takes into account the effect of the drugs that act on cells at certain specific stages of the cell cycle. An optimal control problem is also formulated and solved for both the models so as to obtain the chemotherapeutic schedule which minimizes the final tumour size while taking into account the constraints on drug resistance and toxicity. For the first model a mixed integer dynamic optimization problem and for the second model a dynamic optimization problem are solved. The optimal chemotherapeutic drug administration profiles and the variation of number of cells with time are obtained and analyzed in detail. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:99 / 107
页数:9
相关论文
共 50 条
  • [1] Optimal Delivery of Chemotherapeutic Agents in Cancer
    Dua, Pinky
    Dua, Vivek
    Pistikopoulos, Efstratios N.
    16TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING AND 9TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING, 2006, 21 : 1643 - 1648
  • [2] Advances in Delivery of Chemotherapeutic Agents for Cancer Treatment
    Yadav, Asmita
    Singh, Sakshi
    Sohi, Harmik
    Dang, Shweta
    AAPS PHARMSCITECH, 2021, 23 (01)
  • [3] Advances in Delivery of Chemotherapeutic Agents for Cancer Treatment
    Asmita Yadav
    Sakshi Singh
    Harmik Sohi
    Shweta Dang
    AAPS PharmSciTech, 23
  • [4] Improved Cancer Immunochemotherapy via Optimal Co-delivery of Chemotherapeutic and Immunomodulatory Agents
    Chen, Yichao
    Sun, Jingjing
    Huang, Yixian
    Lu, Binfeng
    Li, Song
    MOLECULAR PHARMACEUTICS, 2018, 15 (11) : 5162 - 5173
  • [5] Polymersomes - a Novel Drug Delivery System for the Delivery of Chemotherapeutic Agents to Oral Cancer Cells
    Colley, H. E.
    Hearnden, V.
    Cecchin, D.
    Armes, S.
    Battaglia, G.
    Murdoch, C.
    Thornhill, M. H.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S254 - S254
  • [6] Electrogels for delivery of chemotherapeutic agents.
    Zakin, MR
    Gelb, AH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U483 - U483
  • [7] Nanoparticles for delivery of chemotherapeutic agents to tumors
    Vijayaraghavalu, Sivakumar
    Raghavan, Derek
    Labhasetwar, Vinod
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2007, 8 (06) : 477 - 484
  • [8] Dendrimers as Carriers for Delivery of Chemotherapeutic Agents
    Medina, Scott H.
    El-Sayed, Mohamed E. H.
    CHEMICAL REVIEWS, 2009, 109 (07) : 3141 - 3157
  • [9] TERATOGENESIS WITH CANCER CHEMOTHERAPEUTIC AGENTS
    BLATTNER, RJ
    WILLIAMSON, AP
    SIMONSEN, L
    ROBERTSON, GG
    JOURNAL OF PEDIATRICS, 1960, 56 (02): : 285 - 293
  • [10] Cancer chemotherapeutic agents for host
    Ishizuka, M
    NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, 1997, 71 (05): : 527 - 529