Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and therapeutic prospect

被引：10

作者：

Du, Yao ^{[1
]}

Zhang, Hui ^{[2
]}

Nie, Xiaoyan ^{[3
]}

Qi, Yajun ^{[4
]}

Shi, Shi ^{[3
]}

Han, Yingying ^{[3
]}

Zhou, Wenchen ^{[3
]}

He, Chaoyong ^{[3
]}

Wang, Lintao ^{[3
]}

机构：

[1] Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Med Sch,Dept Pharm, Nanjing, Peoples R China

[2] Nanjing Med Univ, Childrens Hosp, Dept Stomatol, Nanjing, Peoples R China

[3] China Pharmaceut Univ, Sch Pharm, Nanjing, Peoples R China

[4] Chinese Acad Sci, Inst Canc & Basic Med IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci,Dept Pharm, Hangzhou, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

STING; cGAS; inflammation; cardiovascular diseases; therapy; GMP-AMP SYNTHASE; CYTOSOLIC DNA SENSOR; KAPPA-B ACTIVATION; MITOCHONDRIAL DAMAGE; SUPPRESSIVE OLIGODEOXYNUCLEOTIDES; CELL PROLIFERATION; ATHEROSCLEROSIS; ACID; MECHANISMS; 2ND-MESSENGER;

D O I：

10.3389/fcvm.2022.965726

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sterile inflammation characterized by unresolved chronic inflammation is well established to promote the progression of multiple autoimmune diseases, metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, collectively termed as sterile inflammatory diseases. In recent years, substantial evidence has revealed that the inflammatory response is closely related to cardiovascular diseases. Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway which is activated by cytoplasmic DNA promotes the activation of interferon regulatory factor 3 (IRF3) or nuclear factor-kappa B (NF-kappa B), thus leading to upregulation of the levels of inflammatory factors and interferons (IFNs). Therefore, studying the role of inflammation caused by cGAS-STING pathway in cardiovascular diseases could provide a new therapeutic target for cardiovascular diseases. This review focuses on that cGAS-STING-mediated inflammatory response in the progression of cardiovascular diseases and the prospects of cGAS or STING inhibitors for treatment of cardiovascular diseases.

引用

页数：16

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