Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation

被引:50
作者
Cagnacci, Angelo [1 ]
Bagni, Bruno [2 ]
Zini, Annalisa [1 ]
Cannoletta, Marianna [1 ]
Generali, Matteo [1 ]
Volpe, Annibale [1 ]
机构
[1] Policlin Modena, Dept Obstet Gynecol & Pediat, Obstet & Gynecol Unit, I-41100 Modena, Italy
[2] Policlin Modena, Dept Nucl Med, I-41100 Modena, Italy
关键词
folates; menopause; osteoporosis; homocysteine; bone;
D O I
10.1016/j.bone.2007.10.022
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Elevation of homocysteine is associated with an increased risk for bone fractures. Whether the risk is due to homocysteine or to the reduced levels of cofactors necessary for its metabolisation, such as folates or vitamin B 12, is not completely clear. In this study we wanted to determine whether in postmenopausal women, levels of folates, homocysteine or vitamin B 12 are predictive of the rate of vertebral bone mineral density (BMD) change. The study was conducted at the centre for the menopause of our university hospital. Between September 2001 and March 2002, 161 healthy postmenopausal women volunteered for a cross-sectional evaluation of BMD and levels of serum folates, homocysteine and vitamin B12. Women were recalled for a second evaluation of vertebral BNTD after about 5 years. Women having used anti-resorptive therapies for more than I year were excluded. The analysis was possible in 117 postmenopausal women. The annual rate of vertebral BMD change was independently related to levels of folates (coefficient of regression (CR): 2.040; 95% CI: 0.483, 3.596; p = 0.011), and initial BMD values (CR: -0.060; 95%CI: -0.117, -0.003; p=0.040). No significant relation was found between the change of vertebral BMD and homocysteine or vitamin B12. BMD values at the first (r=0.225; p=0.016) and the second (r=0.206; p=0.027) evaluation were related to levels of folates, but not of homocysteine or of vitamin B12. These data suggest an important role for folates deficiency in the vertebral BMD decline of postmenopausal women. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:314 / 320
页数:7
相关论文
共 39 条
[1]   A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: Longitudinal data from the Danish osteoporosis prevention study [J].
Abrahamsen, B ;
Madsen, JS ;
Tofteng, CL ;
Stilgren, L ;
Bladbjerg, EM ;
Kristensen, SR ;
Brixen, K ;
Mosekilde, L .
JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (04) :723-729
[2]  
ARMITAGE P, 1994, STAT METHODS MED RES, P341
[3]   SKELETAL ABNORMALITIES IN HOMOCYSTINURIA [J].
BRENTON, DP .
POSTGRADUATE MEDICAL JOURNAL, 1977, 53 (622) :488-496
[4]   Age, menopausal status and homocysteine levels in women around menopause [J].
Bruschi, F ;
Daguati, R ;
Parazzini, F ;
Dal Pino, D ;
Fiore, V ;
Di Pace, R ;
Melotti, D ;
Moroni, S ;
Maffioletti, C ;
Rossi, A ;
Crosignani, PG .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2005, 120 (02) :195-197
[5]   NOS isoforms in adult human osteocytes: Multiple pathways of NO regulation? [J].
Caballero-Alias, AM ;
Loveridge, N ;
Lyon, A ;
Das-Gupta, V ;
Pitsillides, A ;
Reeve, J .
CALCIFIED TISSUE INTERNATIONAL, 2004, 75 (01) :78-84
[6]   Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women [J].
Cagnacci, A ;
Baldassari, F ;
Rivolta, G ;
Arangino, S ;
Volpe, A .
BONE, 2003, 33 (06) :956-959
[7]   Folic acid says NO to vascular diseases [J].
Das, UN .
NUTRITION, 2003, 19 (7-8) :686-692
[8]   Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering [J].
Doshi, SN ;
McDowell, IFW ;
Moat, SJ ;
Payne, N ;
Durrant, HJ ;
Lewis, MJ ;
Goodfellow, J .
CIRCULATION, 2002, 105 (01) :22-26
[9]   Gene-nutrient interactions and DNA methylation [J].
Friso, S ;
Choi, SW .
JOURNAL OF NUTRITION, 2002, 132 (08) :2382S-2387S
[10]   Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women [J].
Gerdhem, Paul ;
Ivaska, Kaisa K. ;
Isaksson, Anders ;
Pettersson, Kim ;
Vaananen, H. Kalervo ;
Obrant, Karl J. ;
Akesson, Kristina .
JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (01) :127-134