FN1: A Novel Fusion Partner of ALK in an Inflammatory Myofibroblastic Tumor

被引：35

作者：

Ouchi, Kazutaka ^{[1
]}

Miyachi, Mitsuru ^{[1
]}

Tsuma, Yusuke ^{[1
]}

Tsuchiya, Kunihiko ^{[1
]}

Iehara, Tomoko ^{[1
]}

Konishi, Eiichi ^{[2
]}

Yanagisawa, Akio ^{[2
]}

Hosoi, Hajime ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Pediat, Grad Sch Med Sci, Kyoto 602, Japan

[2] Kyoto Prefectural Univ Med, Dept Pathol, Kyoto 602, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2015年 / 62卷 / 05期

关键词：

ALK gene fusion; FN1; inflammatory myofibroblastic tumor; ANAPLASTIC LYMPHOMA KINASE; IDENTIFICATION; CANCER;

D O I：

10.1002/pbc.25424

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammatory myofibroblastic tumors (IMTs) are rare tumors characterized as low-to-intermediate grade sarcomas. Rearrangements of the anaplastic lymphoma kinase (ALK) gene have been reported in IMT. Here, we describe a novel fusion gene in an IMT tumor specimen. A 12-year-old male was admitted to our hospital with a bladder tumor. We identified the fibronectin 1 gene (FN1) as a fusion partner of ALK using 5RACE. This novel fusion, FN1-ALK, resulted in ALK overexpression in the IMT. This finding should clarify the causes of IMT and facilitate development of novel therapeutics. Pediatr Blood Cancer 2015;62:909-911. (c) 2015 Wiley Periodicals, Inc.

引用

页码：909 / 911

页数：3

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