Future prospects of antibacterial metal nanoparticles as enzyme inhibitor

被引:95
作者
Ahmed, Khan Behlol Ayaz [1 ]
Raman, Thiagarajan [1 ]
Veerappan, Anbazhagan [1 ]
机构
[1] SASTRA Univ, Sch Chem & Biotechnol, Thanjavur 613401, Tamil Nadu, India
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 68卷
关键词
Nanoparticles; Metal nanoparticles; Antibacterial activity; Enzyme inhibitors; SILVER NANOPARTICLES; COPPER NANOPARTICLES; ANTIMICROBIAL ACTIVITY; PHOTODYNAMIC THERAPY; GOLD NANOPARTICLES; ESCHERICHIA-COLI; EFFLUX; DNA; ANTIBIOTICS; MECHANISM;
D O I
10.1016/j.msec.2016.06.034
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Nanoparticles are being widely used as antibacterial agents with metal nanoparticles emerging as the most efficient antibacterial agents. There have been many studies which have reported the mechanism of antibacterial activity of nanoparticles on bacteria. In this review we aim to emphasize on all the possible mechanisms which are involved in the antibacterial activity of nanoparticles and also to understand their mode of action and role as bacterial enzyme inhibitor by comparing their antibacterial mechanism to that of antibiotics with enzyme inhibition as a major mechanism. With the emergence of widespread antibiotic resistance, nanoparticles offer a better alternative to our conventional arsenal of antibiotics. Once the biological safety of these nanoparticles is addressed, these nanoparticles can be of great medical importance in our fight against bacterial infections. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:939 / 947
页数:9
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