Disseminated fusariosis with cerebral involvement in a patient with acute myeloid leukemia: Successful outcome with intrathecal -and systemic antifungal treatment

被引：6

作者：

Risum, Malene ^{[1
,2
]}

Overgaard, Ulrik Malthe ^{[1
]}

Rubek, Niclas ^{[3
]}

Haastrup, Eva Kannik ^{[4
]}

Hare, Rasmus Kroger ^{[5
]}

Helweg-Larsen, Jannik

机构：

[1] Rigshosp, Dept Hematol, Copenhagen, Denmark

[2] Statens Serum Inst, Dept Bacteria Parasites & Fungi, Copenhagen, Denmark

[3] Rigshosp, Dept Otorhinolaryngol Head & Neck Surg & Audiol, Copenhagen, Denmark

[4] Rigshosp, Dept Clin Immunol, Copenhagen, Denmark

[5] Rigshosp, Dept Infect Med, Copenhagen, Denmark

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2022年 / 28卷 / 09期

关键词：

Fusarium; Acute myeloid leukemia; Amphotericin B; Intrathecal treatment; Voriconazole; LIPOSOMAL AMPHOTERICIN-B; CRYPTOCOCCAL MENINGITIS; BRAIN-ABSCESS;

D O I：

10.1016/j.jiac.2022.04.017

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The outcome of invasive fusariosis in hematological patients is usually dismal, particularly in patients with persistent neutropenia. We report a patient with acute myeloid leukemia (AML) with Fusarium dimerum sinusitis with hematogenic dissemination to the brain. Despite surgical debridements of the sinuses and liposomal amphotericin B, voriconazole and terbinafine, there was progression with cerebral involvement after recovery of neutropenia and with detection of F. dimerum in the cerebrospinal fluid. Topical antifungal treatment with amphotericin B deoxycholate (deoxy-AMB) intrathecally was initiated with administration three times a week. After 99 treatments of intrathecal deoxy-AMB, she had regression of the fusarium CNS lesions and is currently in complete remission from AML. This report supports the use of intrathecal amphotericin B for treatment of CNS fusariosis.

引用

页码：1324 / 1328

页数：5

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