An Efficient Protocol for a Pd(OAc)2-Catalyzed Ligand-Free Suzuki Reaction in Toluene

被引：11

作者：

Liu Ning ^{[1
]}

Liu Chun ^{[1
]}

Jin Zilin ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Liaoning, Peoples R China

来源：

CHINESE JOURNAL OF CATALYSIS | 2010年 / 31卷 / 11期

关键词：

Suzuki reaction; arylboronic acid; aryl halide; palladium; ligand-free; toluene; CROSS-COUPLING REACTIONS; FREE PALLADIUM CATALYSIS; ROOM-TEMPERATURE; ARYL CHLORIDES; BOND FORMATION; NANOPARTICLES; WATER;

D O I：

10.1016/S1872-2067(10)60119-2

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient protocol for a Pd(OAc)(2)-catalyzed ligand-free Suzuki reaction of aryl bromides with arylboronic acids in the presence of K3PO4 center dot 7H(2)O in toluene under mild and aerobic conditions afforded cross-coupling products in good to excellent yields. Under the optimized reaction conditions (i.e., 0.5 mmol ArBr, 0.75 mmol ArB(OH)(2), 1 mol% Pd(OAc)(2), 1.0 mmol K3PO4 center dot 7H(2)O, 2 ml toluene), the Suzuki reaction between 4-nitrobromobenzene and phenylboronic acid afforded a 99% isolated yield in 5 min at 75 degrees C and a TOF of up to 1 188 h(-1).

引用

页码：1316 / 1320

页数：5

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