Plasma angiopoietin-1 level, left ventricular ejection fraction, and multivessel disease predict development of 1-year major adverse cardiovascular events in patients with acute ST elevation myocardial infarction - A pilot study

被引：17

作者：

Liu, Kuan-Liang ^{[1
]}

Lin, Shu-Min ^{[2
]}

Chang, Chih-Hsiang ^{[3
]}

Chen, Yung-Chang ^{[3
]}

Chu, Pao-Hsien ^{[1
,4
,5
]}

机构：

[1] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Internal Med,Div Cardiol, Taipei 105, Taiwan

[2] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Thorac Med, Taipei 105, Taiwan

[3] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Nephrol, Taipei 105, Taiwan

[4] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Healthcare Ctr, Taipei 105, Taiwan

[5] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Heart Failure Ctr, Taipei 105, Taiwan

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2015年 / 182卷

关键词：

Angiopoietin; Acute myocardial infarction; Multivessel disease; Major cardiovascular events; ENDOTHELIAL DYSFUNCTION; MORTALITY; THROMBOMODULIN; INFLAMMATION; BALANCE; STROKE; IMPACT; INJURY; CELLS; RISK;

D O I：

10.1016/j.ijcard.2014.12.172

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Patients with acute myocardial infarction (AMI) are frequently complicated with major cardiovascular events (MACEs). Endothelial dysfunction has been found to be involved in pathogenesis of AMI, but its role in development of MACEs after AMI is not clearly investigated. This study aimed to determine whether the plasma markers of endothelial dysfunction could serve as independent predictors for MACEs in patients with AMI. Methods: This prospective study was conducted from March 2010 to July 2012 and enrolled consecutive 132 patients with acute ST elevation myocardial infarction (STEMI) receiving primary percutaneous coronary intervention (PCI). Plasma levels of thrombomodulin (TM), von Willebrand factor (vWF), angiopoietin (Ang)-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) were measured on day 1 of AMI. The development of MACEs at 1-year follow-up was recorded. Result: Patients with STEMI who developed MACEs had increased heart rate on admission (86 +/- 24 vs. 74 +/- 20 bpm, p = 0.006), lower left ventricular ejection fraction (LVEF) (49.0 +/- 12.4 vs. 57.2 +/- 12.4%, p = 0.002), and higher incidence of multivessel disease (66.7% vs. 42.2%, p = 0.018) comparing with those without MACEs. Plasma level of Ang-1 was lower in patients with MACEs than in those without (21,165 +/- 16,281 vs. 31,411 +/- 21,593 pg/mL, p = 0.018). In multivariate analysis, Ang-1 level < median value (OR 2.977, 95% CI 1.16-7.63, p = 0.023), LVEF (OR 0.958, 95% CI 0.92-0.99, p = 0.022) and multivessel disease (OR 3.013, 95% CI 1.19-7.60, p = 0.019) independently predicted 1-year MACEs. Conclusion: Decreased plasma Ang-1 levels on admission, LVEF and multivessel disease independently predicted the development of 1-year MACEs in patients with STEMI. These results suggest that endothelial dysfunction may play an important role in mediating MACEs in patients with STEMI. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：155 / 160

页数：6

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