Pd-Catalyzed Dearboxylative Heck Coupling with Dioxygen as the Terminal Oxidant

被引：95

作者：

Fu, Zhengjiang ^{[1
]}

Huang, Shijun ^{[1
]}

Su, Weiping ^{[1
]}

Hong, Maochun ^{[1
]}

机构：

[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 21期

关键词：

ARENE CARBOXYLIC-ACIDS; MOLECULAR-OXYGEN; BENZOIC-ACIDS; VERSATILE CATALYST; DECARBOXYLATIVE OLEFINATION; OXIDATIVE AMINATION; DIRECT ARYLATION; ARYL BROMIDES; H ACTIVATION; ALKENES;

D O I：

10.1021/ol102158n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd-catalyzed decarboxylative Heck coupling of aromatic carboxylic acids with various olefins is developed using O-2 as the terminal oxidant. Enhancement of O-2 pressure leads to improving reaction turnover in this transformation and allows significantly reducing catalyst loading for efficient conversion of electron-rich benzoic acids. A Pd catalyst supported by a carbene ligand enables using electron-deficient benzoic acids as coupling partners.

引用

页码：4992 / 4995

页数：4

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