Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study

被引:20
作者
Kalicinska, Elzbieta [1 ]
Biernat, Monika [1 ]
Rybka, Justyna [1 ]
Zinczuk, Aleksander [2 ,3 ]
Janocha-Litwin, Justyna [2 ]
Rosiek-Biegus, Marta [4 ]
Morawska, Marta [5 ,6 ]
Waszczuk-Gajda, Anna [7 ]
Drozd-Sokolowska, Joanna [7 ]
Szukalski, Lukasz [8 ]
Rymko, Marcin [9 ]
Jablonowska, Paula [1 ]
Simon, Krzysztof [2 ]
Wrobel, Tomasz [1 ]
机构
[1] Wroclaw Med Univ, Dept & Clin Hematol Blood Neoplasms & Bone Marrow, PL-50367 Wroclaw, Poland
[2] Wroclaw Med Univ, Dept Infect Dis & Hepatol, PL-51149 Wroclaw, Poland
[3] Wroclaw Med Univ, Dept Forens Med, PL-50372 Wroclaw, Poland
[4] Wroclaw Med Univ, Dept Internal Med Pneumol & Allergol, PL-50367 Wroclaw, Poland
[5] Med Univ Lublin, Expt Hematooncol Dept, PL-20093 Lublin, Poland
[6] St Johns Canc Ctr, Hematol Dept, PL-20090 Lublin, Poland
[7] Med Univ Warsaw, Dept Hematol Transplantat & Internal Med, PL-02097 Warsaw, Poland
[8] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Hematol, PL-85168 Bydgoszcz, Poland
[9] SSM Nicolaus Copernicus, Dept Hematol & Bone Marrow Transplantat, PL-87100 Torun, Poland
关键词
endothelial dysfunction; EASIX; COVID-19; hematological cancer; lactate dehydrogenase; platelet count; creatinine; DISEASE;
D O I
10.3390/jcm10194373
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score has been used as a simple predictor of overall survival (OS) in specific groups of hematological cancer patients. EASIX, as a biomarker of endothelial dysfunction, might play a prognostic role in patients with COVID-19. Here, we performed a comprehensive retrospective analysis of the EASIX score in 523 hospitalized COVID-19 patients with or without coexisting hematological cancer. Hematological cancer COVID-19 patients had higher EASIX scores compared to the overall population with COVID-19. In hematological patients, EASIX was a strong predictor of the occurrence of sepsis during COVID-19. Our findings demonstrated EASIX as a strong predictor of intensive care unit admission, in-hospital mortality, the occurrence of acute renal failure and the need for hemodialysis, both in hematological and non-hematological COVID-19 patients. Patients with a high EASIX score on COVID-19 diagnosis had significantly inferior OS compared to patients with low EASIX. We showed for the first time that EASIX might serve as a simple, universal prognostic tool of OS in both hematological and non-hematological COVID-19 patients.
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页数:16
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