Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2

被引：7

作者：

Levy, Joshua M. ^{[1
,2
]}

Frediani, Jennifer K. ^{[2
,3
]}

Tyburski, Erika A. ^{[1
,4
]}

Wood, Anna ^{[7
]}

Figueroa, Janet ^{[7
]}

Kempker, Russell R. ^{[1
,5
]}

Rebolledo, Paulina A. ^{[1
,5
,6
]}

Gonzalez, Mark D. ^{[1
,8
,9
]}

Sullivan, Julie ^{[1
,7
]}

Vos, Miriam B. ^{[1
,7
,8
]}

O'Neal, Jared ^{[1
]}

Martin, Greg S. ^{[1
,5
]}

Lam, Wilbur A. ^{[1
,4
,9
,10
,11
]}

Waggoner, Jesse J. ^{[1
,5
,6
]}

机构：

[1] Atlanta Ctr Microsyst Engn Point Care Technol, Atlanta, GA 30342 USA

[2] Emory Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Atlanta, GA USA

[3] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA

[4] Georgia Inst Technol, Atlanta, GA 30332 USA

[5] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30322 USA

[6] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[7] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA

[8] Childrens Healthcare Atlanta, Atlanta, GA USA

[9] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[10] Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders Ctr, Atlanta, GA 30329 USA

[11] Emory Univ, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

D O I：

10.1038/s41598-021-94547-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88-1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.

引用

页数：5

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