The Pursuit of Therapeutic Biomarkers with High-Throughput Cancer Cell Drug Screens

被引：22

作者：

Williams, Steven P. ^{[1
]}

McDermott, Ultan ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton CB10 1SA, England

来源：

CELL CHEMICAL BIOLOGY | 2017年 / 24卷 / 09期

关键词：

GENOME; SENSITIVITY; IDENTIFICATION; CONSISTENCY; SATURATION; DISCOVERY; METRICS;

D O I：

10.1016/j.chembiol.2017.06.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the last decade we have witnessed tremendous advances in our understanding of the landscape of the molecular alterations that underpin many of the most prevalent cancers, in the use of automated high-throughput platforms for high-throughput drug screens in cancer cells, in the creation of more clinically relevant cancer cell models, and lastly in the development of more useful computational approaches in the pursuit of biomarkers of drug response. Separately, each of these improvements will undoubtedly lead to improvements in the treatment of cancer patients but to fulfill the promise of truly personalized cancer medicine, we must bring these disciplines together in a truly multidisciplinary fashion.

引用

页码：1066 / 1074

页数：9

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