FGF23 and Nutritional Metabolism

被引：22

作者：

Pool, Lindsay R. ^{[1
]}

Wolf, Myles ^{[2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Ctr Translat Hlth & Metab, Chicago, IL 60611 USA

[2] Duke Univ, Sch Med, Dept Med, Div Nephrol, Durham, NC 27703 USA

来源：

ANNUAL REVIEW OF NUTRITION, VOL 37 | 2017年 / 37卷

关键词：

fibroblast growth factor 23; chronic kidney disease; cardiovascular disease; phosphate; nutritional metabolism; GROWTH-FACTOR; 23; CHRONIC KIDNEY-DISEASE; LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR EVENTS EVOLVE; CONTAINING FOOD-ADDITIVES; STAGE RENAL-DISEASE; PARATHYROID-HORMONE; SERUM PHOSPHATE; MINERAL METABOLISM; HEART-FAILURE;

D O I：

10.1146/annurev-nutr-071816-064620

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The discovery of fibroblast growth factor 23 (FGF23) has provided a more complete understanding of the regulation of phosphate and mineral homeostasis in health and in chronic kidney disease. It has also offered new insights into stratification of risk of cardiovascular events and death among patients with chronic kidney disease and the general population. In this review, we provide an overview of FGF23 biology and physiology, summarize clinical outcomes that have been associated with FGF23, discuss potential mechanisms for these observations and their public health implications, and explore clinical and population health interventions that aim to reduce FGF23 levels and improve public health.

引用

页码：247 / 268

页数：22

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