Microfluidic-Mass Spectrometry Interfaces for Translational Proteomics

被引：37

作者：

Pedde, R. Daniel ^{[1
,2
]}

Li, Huiyan ^{[2
]}

Borchers, Christoph H. ^{[2
,3
,4
,5
]}

Akbari, Mohsen ^{[1
,6
,7
]}

机构：

[1] Univ Victoria, Dept Mech Engn, Lab Innovat Microengn LiME, 3800 Finnerty Rd, Victoria, BC V8P 5C2, Canada

[2] Univ Victoria, Univ Victoria Genome British Columbia Prote Ctr, 3101-4464 Markham St, Victoria, BC V8Z 7X8, Canada

[3] Univ Victoria, Dept Biochem & Microbiol, 3800 Finnerty Rd, Victoria, BC V8P 5C2, Canada

[4] McGill Univ, Gerald Bronfman Dept Oncol, 5100 de Maisonneuve Blvd West,Suite 720, Montreal, PQ H4A 3T2, Canada

[5] McGill Univ, Jewish Gen Hosp, Prote Ctr, 3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada

[6] Univ Victoria, CBR, 3800 Finnerty Rd, Victoria, BC V8P 5C2, Canada

[7] Univ Victoria, Ctr Adv Mat & Related Technol CAMTEC, 3800 Finnerty Rd, Victoria, BC V8P 5C2, Canada

来源：

TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; PROTEIN-LIGAND INTERACTIONS; MALDI-MS; ELECTROSPRAY-IONIZATION; CAPILLARY-ELECTROPHORESIS; DIGITAL MICROFLUIDICS; CLINICAL UTILITY; PLATFORM; PLASMA; TECHNOLOGIES;

D O I：

10.1016/j.tibtech.2017.06.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interfacing mass spectrometry (MS) with microfluidic chips (mchip-MS) holds considerable potential to transform a clinician's toolbox, providing translatable methods for the early detection, diagnosis, monitoring, and treatment of non-communicable diseases by streamlining and integrating laborious sample preparation workflows on high-throughput, user-friendly platforms. Overcoming the limitations of competitive immunoassays - currently the gold standard in clinical proteomics - mchip-MS can provide unprecedented access to complex proteomic assays having high sensitivity and specificity, but without the labor, costs, and complexities associated with conventional MS sample processing. This review surveys recent mchip-MS systems for clinical applications and examines their emerging role in streamlining the development and translation of MS-based proteomic assays by alleviating many of the challenges that currently inhibit widespread clinical adoption.

引用

页码：954 / 970

页数：17

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