LUMILIXIMAB MODULATES PI3-K/AKT PATHWAY AND INDUCES APOPTOSIS IN CLL CELLS

被引:0
|
作者
Shehata, M. [1 ]
Schnabl, S. [1 ]
Ponath, E. [1 ]
Demirtas, D. [1 ]
Hilgarth, M. [1 ]
Badrnya, S. [1 ]
Tauber, S. [1 ]
Bilban, M. [1 ]
Eigenberger, K. [1 ]
Schwarzmeier, J. [1 ]
Gaiger, A. [1 ]
Hubmann, R. [1 ]
Zielinski, C. [1 ]
Hughes, S. [2 ]
Maclaren, A. [2 ]
Jaeger, U. [1 ]
机构
[1] Med Univ Vienna, Vienna, Austria
[2] Biogen Idec Inc, Maidenhead, Berks, England
来源
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
0117
引用
收藏
页码:47 / 47
页数:1
相关论文
共 50 条
  • [1] Lumiliximab Triggers Apoptosis Mechanisms in CLL Cells through the Inhibition of PI3-K/Akt Pathway
    Shehata, Medhat
    Schnabl, Susanne
    Ponath, Elena
    Tauber, Stefanie
    Demirtas, Dita
    Hilgarth, Martin
    Bilban, Martin
    Badrnya, Sigrun
    Fleiss, Karin
    Schwarzmeier, Josef D.
    Gaiger, Alexander
    Hubmann, Rainer
    Zielinski, Christoph C.
    Hughes, Steve
    Maclaren, Ann
    Jaeger, Ulrich
    BLOOD, 2009, 114 (22) : 936 - 936
  • [2] Lymphoid microenvironment inhibits apoptosis in B-CLL cells: Involvement of PI3-K/AKT pathway and PTEN.
    Shehata, Medhat
    Schnabl, Susanne
    Demirtas, Dita
    Schwarzmeier, Josef D.
    Hilgarth, Martin
    Duechler, Markus
    Gaiger, Alexander
    Hubmann, Rainer
    Jaeger, Ulrich
    BLOOD, 2006, 108 (11) : 418A - 418A
  • [3] Selenite inhibits apoptosis via activation of the PI3-K/Akt pathway
    Yoon, SO
    Park, SJ
    Chung, AS
    CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS, 2002, 973 : 221 - 223
  • [4] Inositol pentakisphosphate promotes apoptosis through the PI3-K/Akt pathway
    Piccolo, E
    Vignati, S
    Maffucci, T
    Innominato, PF
    Riley, AM
    Potter, BVL
    Pandolfi, PP
    Broggini, M
    Iacobelli, S
    Innocenti, P
    Falasca, M
    ONCOGENE, 2004, 23 (09) : 1754 - 1765
  • [5] Interaction between B-CLL cells and lymphoid microenvironment leads to activation of PI3-K/Akt pathway and inhibition of apoptosis.
    Shehata, M
    Schnabl, S
    Demirtas, D
    Schwarzmeier, JD
    Hilgarth, M
    Duechler, M
    Hubmann, R
    Jaeger, U
    BLOOD, 2005, 106 (11) : 595A - 595A
  • [6] Chamaejasmine induces apoptosis in HeLa cells through the PI3K/Akt signaling pathway
    Qian, Sumin
    Li, Meng
    ANTI-CANCER DRUGS, 2017, 28 (01) : 40 - 50
  • [7] Geldanamycin induces apoptosis in rheumatoid synovial cells by down-regulating MAPK and PI3-K pathway.
    Hashiramoto, A
    Miura, Y
    Murata, M
    Sakai, C
    Terashima, Y
    Abe, S
    Koyama, K
    Nakagawa, N
    Saegusa, Y
    Shiozawa, K
    Yoshiya, S
    Kurosaka, M
    Shiozawal, S
    ARTHRITIS AND RHEUMATISM, 2004, 50 (09): : S567 - S567
  • [8] Oleate induces an insulin resistance 'selective' for the PI3-K/Akt pathway in cultured human vascular smooth muscle cells
    Russo, I.
    Del Mese, P.
    Viretto, M.
    Doronzo, G.
    Mattiello, L.
    Anfossi, G.
    Trovati, M.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2008, 38 : 55 - 55
  • [9] Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium
    Veillette, Annabelle
    Grenier, Kathy
    Brasseur, Kevin
    Frechette-Frigon, Guylaine
    Leblanc, Valerie
    Parent, Sophie
    Asselin, Eric
    BIOLOGY OF REPRODUCTION, 2013, 88 (03)
  • [10] Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway
    Lei, Jiaming
    Yang, Jianbao
    Cheng, Shijiao
    Lu, Feifei
    Wu, Zihan
    Wang, Ziyi
    Wang, Ziqi
    Sun, Chenyu
    Lin, Li
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2024, 28 (06)