Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes

被引:226
作者
Cole, Steven W. [1 ,2 ,3 ]
Hawkley, Louise C. [4 ,5 ]
Arevalo, Jesusa M. G. [1 ]
Cacioppo, John T. [4 ,5 ]
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Div Hematol Oncol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Univ Calif Los Angeles AIDS Inst, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Univ Calif Los Angeles Mol Biol Inst, Jonsson Comprehens Canc Ctr, Norman Cousins Ctr, Los Angeles, CA 90095 USA
[4] Univ Chicago, Dept Psychol, Chicago, IL 60637 USA
[5] Univ Chicago, Ctr Cognit & Social Neurosci, Chicago, IL 60637 USA
基金
美国国家卫生研究院;
关键词
social genomics; inflammation; bioinformatics; ecological immunology; CHRONIC STRESS; IMMUNE-SYSTEM; SUPPORT; INFLAMMATION; MACROPHAGES; MECHANISMS; EVOLUTION; SURVIVAL; INSIGHTS; SUBSETS;
D O I
10.1073/pnas.1014218108
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To clarify the biological rationale for social regulation of gene expression, this study sought to identify the specific immune cell types that are transcriptionally sensitive to subjective social isolation (loneliness). Using reference distributions for the expression of each human gene in each major leukocyte subtype, we mapped the cellular origin of transcripts found to be differentially expressed in the circulating immune cells from chronically lonely individuals. Loneliness-associated genes derived primarily from plasmacytoid dendritic cells, monocytes, and, to a lesser extent, B lymphocytes. Those dynamics reflected per-cell changes in the expression of inducible genes and related more strongly to the subjective experience of loneliness than to objective social network size. Evolutionarily ancient myeloid antigen-presenting cells appear to have evolved a transcriptional sensitivity to socioenvironmental conditions that may allow them to shift basal gene expression profiles to counter the changing microbial threats associated with hostile vs. affine social conditions.
引用
收藏
页码:3080 / 3085
页数:6
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