Dextran-crosslinked glucose responsive nanogels with a self-regulated insulin release at physiological conditions

被引：27

作者：

Elshaarani, Tarig ^{[1
]}

Yu, Haojie ^{[1
]}

Wang, Li ^{[1
]}

Lin, Long ^{[2
]}

Wang, Nan ^{[1
]}

Naveed, Kaleem Ur Rahman ^{[1
]}

Zhang, Li ^{[3
]}

Han, Yin ^{[3
]}

Fahad, Shah ^{[1
]}

Ni, Zhipeng ^{[1
]}

机构：

[1] Zhejiang Univ, State Key Lab Chem Engn, Coll Chem & Biol Engn, Hangzhou 310027, Peoples R China

[2] Univ Leeds, Dept Colour Sci, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England

[3] Zhejiang Inst Med Device Testing, Hangzhou 310018, Peoples R China

来源：

EUROPEAN POLYMER JOURNAL | 2020年 / 125卷

关键词：

Nanogel; Dextran; Glucose sensing; Insulin delivery; N-ISOPROPYLACRYLAMIDE; BLOCK-COPOLYMERS; ACID; POLYMER; TEMPERATURE; BEARING; GEL;

D O I：

10.1016/j.eurpolymj.2020.109505

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Different glucose-responsive nanogels of N-isopropylacrylamide (NIPAM) and 4-(1,6-dioxo-2,5-diaza-7-oxamyl) phenylboronic acid (DDOPBA) were synthesized using dextran-grafted maleic acid (Dex-MA) as a crosslinker. The formed nanogels (P(NIPAM-co-Dex-co-DDOPBA)s) were verified by H-1 NMR, TEM, DLS and X-ray photoelectron spectroscopy (XPS). The incorporation of DDOPBA provided a remarkable sensitivity towards glucose in physiological pH due to the existence of electron-withdrawing group in its structure. Similarly, the hydrophilic Dex-MA modulated the temperature-sensitivity near physiological temperature. The nanogels exhibited high insulin loading capacity and encapsulation efficiency and the in vitro release profiles demonstrated a glucose dependant release of the payload at physiological pH and temperature.

引用

页数：11

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