Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells

被引：14

作者：

He, Feng ^{[1
,2
,3
]}

Ma, Ning ^{[4
]}

Midorikawa, Kaoru ^{[1
]}

Hiraku, Yusuke ^{[1
]}

Oikawa, Shinji ^{[1
]}

Mo, Yingxi ^{[5
]}

Zhang, Zhe ^{[3
]}

Takeuchi, Kazuhiko ^{[2
]}

Murata, Mariko ^{[1
]}

机构：

[1] Mie Univ, Dept Environm & Mol Med, Grad Sch Med, Tsu, Mie, Japan

[2] Mie Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Tsu, Mie, Japan

[3] Guangxi Med Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Nanning, Peoples R China

[4] Suzuka Univ Med Sci, Grad Sch Hlth Sci, Div Hlth Sci, Suzuka, Mie, Japan

[5] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Res, Nanning, Peoples R China

来源：

TAURINE 11 | 2019年 / 1155卷

关键词：

Taurine; Nasopharyngeal carcinoma; PTEN; p53; BARR-VIRUS INFECTION; EPITHELIAL-CELLS; APOPTOSIS; CANCER;

D O I：

10.1007/978-981-13-8023-5_49

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Taurine displays anti-tumor activity in some kinds of human cancers. However, the underlying mechanisms are poorly understood. Epstein-Barr virus-related nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer in Southeast Asia with the highest incidence in South China. We examined an apoptosis-inducing effect of taurine against NPC cells (HK1 and HK1-EBV) to clarify the mechanisms of anti-tumor effects of taurine by immunocytochemical methods. We observed that taurine induced cleavage of caspase-9/3 in a concentration-dependent manner, suggesting the involvement of mitochondrial apoptotic signals. Both PTEN and p53 activation were detected in a dose-dependent manner after taurine treatment in NPC cells. In conclusion, taurine may play an anti-tumor role by activating tumor suppressor PTEN and p53.

引用

页码：533 / 541

页数：9

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