Widespread role for the flowering-time regulators FCA and FPA in RNA-mediated chromatin silencing

被引：142
作者：
Baeurle, Isabel [1 ]
Smith, Lisa
Baulcombe, David C.
Dean, Caroline
机构：
[1] John Innes Ctr Plant Sci Res, Dept Cell & Dev Biol, Norwich NR4 7UH, Norfolk, England
[2] Sainsbury Lab, Norwich NR4 7UH, Norfolk, England
来源：
SCIENCE | 2007年 / 318卷 / 5847期
基金：
英国自然环境研究理事会;
关键词：
D O I：
10.1126/science.1146565
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The RRM-domain proteins FCA and FPA have previously been characterized as flowering-time regulators in Arabidopsis. We show that they are required for RNA-mediated chromatin silencing of a range of loci in the genome. At some target loci, FCA and FPA promote asymmetric DNA methylation, whereas at others they function in parallel to DNA methylation. Female gametophytic development and early embryonic development are particularly susceptible to malfunctions in FCA and FPA. We propose that FCA and FPA regulate chromatin silencing of single and low-copy genes and interact in a locus-dependent manner with the canonical small interfering RNA-directed DNA methylation pathway to regulate common targets.
引用
收藏
页码：109 / 112
页数：4
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