Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens

被引：0

作者：

Toledo, Victor ^{[1
]}

Ramirez, Galia ^{[1
]}

Valck, Carolina ^{[1
]}

Lopez, Nandy ^{[1
]}

Ribeiro, Carolina H. ^{[1
]}

Maldonado, Ismael ^{[1
]}

Aguilar, Lorena ^{[1
]}

Lemus, David ^{[2
]}

Ferreira, Arturo ^{[1
]}

机构：

[1] Univ Chile, Lab Immunol Microbial Aggress, Immunol Disciplinary Program, ICBM,Fac Med, Santiago, Chile

[2] Univ Chile, Disciplinary Program Dev Anat & Biol, Fac Med, ICBM, Santiago, Chile

来源：

BIOLOGICAL RESEARCH | 2010年 / 43卷 / 03期

关键词：

Calreticulin; T; cruzi; anti-angiogenesis; HUMAN-COMPLEMENT; 1ST COMPONENT; TUMOR-GROWTH; ANGIOGENESIS; INFECTION; FRAGMENTS; PROTEIN;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Angiogenesis is a complex multi-step process of neovascularization arising from preexisting blood vessels whose generation is regulated by pro- and anti-angiogenic factors. Both Trypanosoma cruzi calreticulin (TcCRT) and its human counterpart (HuCRT) are antiangiogenic. This is the first report where the TcCRT and HuCRT anti-angiogenic properties are compared in vivo. In the chick embryonic chorioallantoid membrane assay (CAM) and at equimolar concentrations, TcCRT displayed significantly higher antiangiogenic activities than its human counterpart. LPS had marginal effects at the concentrations present in the recombinant protein preparations and the TcCRT antiangiogenic effects were largely inhibited by specific polyclonal antibodies, thus, reinforcing the fact that the observed TcCRT effects can be attributed to the parasite-derived molecule and not to the endotoxin. The antiangiogenic TcCRT effects correlate with its anti-tumor in vivo effects, as recently shown in our laboratory.

引用

页码：287 / 289

页数：3