A Diels-Alder strategy for the building of imidazo[4,5-g]quinoline-4,9-dione derivatives

被引：7

作者：

Alvarez, F

Taleb, A

Gentili, J

Nebois, P

Terreux, R

Domard, M

Thozet, A

Merle, D

Fillion, H

Walchshofer, N

机构：

[1] Univ Lyon 1, ISPB, EA 3741, Ecosyst & Mol Bioact, F-69373 Lyon, France

[2] Univ Lyon 1, Crystallog Lab, CNRS, F-69622 Villeurbanne, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 09期

关键词：

benzimidazole; cycloaddition; nitrogen heterocycles; quinones;

D O I：

10.1002/ejoc.200400803

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzimidazole-4,7-diones 3a and 3b were synthesized and submitted to hetero Diels-Alder reactions with azadienes 4 and 5 to afford imidazo[4,5-g]quinoline-4,9-diones 6-9. The structure of the latter was assigned by X-ray diffraction, H-1 NMR NOE DIFF experiments or by a molecular dynamics study. (c) Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1903 / 1908

页数：6

共 27 条

[1] Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase [J].