Mood stabilizers and ion regulation

被引:31
作者
El-Mallakh, RS [1 ]
Huff, MO [1 ]
机构
[1] Univ Louisville, Sch Med, Dept Psychiat & Behav Sci, Mood Disorders Res Program, Louisville, KY 40292 USA
关键词
D O I
10.1080/10673220127873
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Understanding the pathogenesis and pathophysiology of bipolar disorder is a prerequisite for accelerating the development of effective therapeutic agents and interventions. One of the best clues to these processes lies in shared mechanisms of action of mood-stabilizing agents. All effective mood stabilizers share the ability to attenuate the influx and intracellular accumulation of sodium in an activity-dependent manner. When coupled with independent observations of aberrant ion regulation in mania and bipolar depression, this shared characteristic is potentially significant. A unified hypothesis is presented in which lithium. valproic acid, and carbamazepine are suggested to produce antimanic effects by modifying ion flux and intracellular ion concentrations.
引用
收藏
页码:23 / 32
页数:10
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