Efficient synthesis of new 3-heteroaryl-1-functionalized 1H-indazoles

被引：16

作者：

Fraile, Alberto ^{[1
]}

Rosario Martin, M. ^{[1
]}

Garcia Ruano, Jose Luis ^{[1
]}

Antonio Diaz, Juan ^{[2
]}

Arranz, Esther ^{[2
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

[2] Ctr Invest Sanofi Aventis, Madrid 28925, Spain

来源：

TETRAHEDRON | 2011年 / 67卷 / 01期

关键词：

1H-Indazoles; Azoles; Cross-coupling; C-C coupled heterocycles; Thiazole; CROSS-COUPLING REACTIONS; INHIBITORS; ANALOGS; DESIGN; 3-BENZIMIDAZOL-2-YL-1H-INDAZOLES; DERIVATIVES; ARYLATIONS; HALIDES; POTENT; SERIES;

D O I：

10.1016/j.tet.2010.11.021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient synthesis of novel 3-heteroaryl N-1-functionalized indazoles, via palladium cross-coupling reactions of ethyl (3-iodo-1H-indazol-1-yl)acetate with 2- and 3-pyrrolylboronic acids, 2-, 4- and 5-thiazolylstannanes, and other heteroarylmetallated derivatives are reported. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：100 / 105

页数：6

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