Individual Differences in Socioaffective Skills Influence the Neural Bases of Fear Processing: The Case of Alexithymia

被引:45
作者
Pouga, Lydia [1 ,2 ]
Berthoz, Sylvie [3 ,4 ]
de Gelder, Beatrice [5 ]
Grezes, Julie [1 ,2 ]
机构
[1] Ecole Normale Super, INSERM, Cognit Neurosci Lab, U960, F-75005 Paris, France
[2] Ecole Normale Super, DEC, F-75005 Paris, France
[3] Paris Descartes Univ, INSERM, IMM, PSIGIAM,U669, Paris, France
[4] Univ Paris 11, INSERM, IMM, PSIGIAM,U669, Orsay, France
[5] Tilburg Univ, Cognit & Affect Neurosci Lab, Tilburg, Netherlands
关键词
fear; body expressions; alexithymia; emotional regulation; fMRI; POSITRON-EMISSION-TOMOGRAPHY; MEDIAL PREFRONTAL CORTEX; EMOTIONAL AWARENESS; PREMOTOR CORTEX; IMPAIRED RECOGNITION; FACIAL EXPRESSIONS; BRAIN ACTIVATION; CUTOFF SCORES; AMYGDALA; STIMULATION;
D O I
10.1002/hbm.20953
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Being exposed to fear signals makes us feel threatened and prompts us to prepare an adaptive response. In our previous studies, we suggested that amygdala (AMG) and premotor cortex (PM) play a role in the preparation of the observers' motor response required by the situation. The present experiment aimed at assessing how interindividual differences in alexithymia-a personality trait associated with deficits in emotional reactivity and regulation-influence the neural network associated with the perception of fear. Using fMRI, we scanned 34 healthy subjects while they were passively observing fearful body expressions. Applying a dimensional approach, we performed correlation analyses between fear-related brain areas and alexithymia scores among all participants. Using a categorical approach, we conducted a between-group comparison (13 high vs. 12 low-alexithymia subjects). Our results were three-fold. First, the right AMG activity in response to fearful stimuli was negatively correlated with the level of difficulty to identify emotions. Second, PM activity was linked to reduced subjective emotional reactivity. Third, the between-group comparison revealed greater activity in anterior cingulate cortex (ACC) for high than low-alexithymia scorers. Moreover, the relationship between ACC and PM was in opposite direction in individuals with high (negative link) and low (positive link) alexithymia. Therefore, compared to our previous findings, we hereby further reveal how ACC interacts with PM to sustain self-regulation of one's own emotional state in response to threatening social signals. Moreover, this neural mechanism could account for the description of the "cold-blooded'' personality of individuals with alexithymia. Hum Brain Mapp 31:1469-1481,2010. (c) 2010 Wiley-Liss, Inc.
引用
收藏
页码:1469 / 1481
页数:13
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