AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

被引:46
作者
Diaz-Alonso, Javier [1 ,2 ]
Nicoll, Roger A. [3 ,4 ]
机构
[1] Dept Anat & Neurobiol, Irvine, CA USA
[2] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92717 USA
[3] Dept Cellular & Mol Pharmacol, Irvine, CA USA
[4] Univ Calif San Francisco, Physiol, San Francisco, CA 94143 USA
关键词
Long-term potentiation; LTP; AMPAR amino-terminal domain; TARP; Synaptic plasticity; HIPPOCAMPAL SYNAPTIC PLASTICITY; GLUTAMATE RECEPTORS; KINASE-II; REGULATORY PHOSPHORYLATION; EXTRACELLULAR-MATRIX; EXCITATORY SYNAPSES; SUBUNIT COMPOSITION; SURFACE-DIFFUSION; CRYSTAL-STRUCTURE; NMDA RECEPTORS;
D O I
10.1016/j.neuropharm.2021.108710
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. This article is part of the special Issue on 'Glutamate Receptors - AMPA receptors'.
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页数:9
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