AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. This article is part of the special Issue on 'Glutamate Receptors - AMPA receptors'.
机构:Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA
Adesnik, Hillel
Nicoll, Roger A.
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Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA
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Louisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USALouisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USA
Andrásfalvy, BK
Magee, JC
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Louisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USALouisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USA
机构:Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA
Adesnik, Hillel
Nicoll, Roger A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA
机构:
Louisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USALouisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USA
Andrásfalvy, BK
Magee, JC
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USALouisiana State Univ, Ctr Hlth Sci, Ctr Neurosci, New Orleans, LA 70112 USA