The interaction studies of novel imine ligands and palladium(II) complexes with DNA and BSA for drug delivery application: The anti-cancer activity and molecular docking evaluation

被引：15
作者：
Karami, Kazem [1 ]
Mehvari, Fariba [1 ]
Ramezanzade, Vahid [1 ]
Zakariazadeh, Mostafa [2 ]
Kharaziha, Mahshid [3 ]
Ramezanpour, Azar [1 ]
机构：
[1] Isfahan Univ Technol, Dept Chem, 8415683111, Esfahan, Iran
[2] Payame Noor Univ, Fac Sci, Dept Biochem, Tehran, Iran
[3] Isfahan Univ Technol, Dept Mat Engn, 8415683111, Esfahan, Iran
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2022年 / 362卷
关键词：
Palladium(II) complexes; Albumin nanoparticles; Drug release; Molecular docking; IN-VITRO CYTOTOXICITY; SCHIFF-BASE; CRYSTAL-STRUCTURE; BINDING; NANOPARTICLES; RUTHENIUM(II); ANTIBACTERIAL; PLATINUM(II); BEARING; CU(II);
D O I：
10.1016/j.molliq.2022.119493
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In the effort to discover anti-cancer drugs and improve the therapeutic efficacy of metal-based compounds, two new imine ligands and their palladium [Pd (II)] complexes were synthesized and characterized by several spectroscopic techniques. Besides, a groove interaction of samples with deoxyribonucleic acid was observed, and the interaction with bovine serum albumin (BSA) revealed the remarkable binding affinity of samples. Also, the quenching properties of BSA were measured by competitive site markers experiments, which they preferred site I and II on BSA. Then, BSA nanoparticles (BSA-NPs) were prepared using the desolvation method and characterized for the drug delivery system of synthesized samples. Next, they were loaded on the BSA-NPs, which their morphology displayed high compatibility with one another. Further, the in-vitro comparative drug release activity between samples and loaded samples was examined, which the release profiles exhibited a bi-phase pattern involving an initial burst release, obeyed a sustained pattern. Additionally, the cytotoxicity effects of samples were evaluated against the breast cancer cell lines. Based on the calculated IC50, BSA-NPs exhibited the significant role by enhancing the cytotoxicity. Furthermore, the in-silico molecular docking simulation of the samples was examined, and the obtained results were in agreement with the empirical results. (c) 2022 Published by Elsevier B.V.
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页数：15
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