Functional Capillary Density Decreases after the First Week of Life in Term Neonates

被引:33
作者
Top, A. P. C. [1 ,2 ]
van Dijk, M. [2 ]
van Velzen, J. E. [2 ]
Ince, C. [3 ]
Tibboel, D. [2 ]
机构
[1] Addenbrookes Hosp, Pediat Intens Care Unit, Dept Pediat Intens Care, Cambridge CB2 0QQ, England
[2] Sophia Childrens Univ Hosp, Erasmus MC, Dept Pediat Surg, Rotterdam, Netherlands
[3] Erasmus MC, Dept Intens Care, Rotterdam, Netherlands
关键词
Microcirculation; Functional capillary density; Orthogonal polarization spectral imaging; SKIN BLOOD-FLOW; SEPTIC SHOCK; INFANTS; MICROCIRCULATION; FAILURE;
D O I
10.1159/000316945
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Changes in the microcirculation have been recognized to play a crucial role in many disease processes. In premature neonates, functional capillary density (FCD) decreases during the first months of life. Objectives: The aims of this study were to obtain microcirculatory parameters in term neonates and older children who did not present with compromised respiration or circulation and to determine developmental changes in the microcirculation in young children. Methods: This single-center prospective observational study was performed at a level III university children's hospital. Subjects eligible for inclusion were children up to the age of 3 years who did not have any respiratory compromise, circulatory compromise or signs of dehydration. The buccal mucosa of 45 children was assessed, using orthogonal polarization spectral imaging. Results: We found a significantly higher FCD in neonates younger than 1 week compared with older children. The median FCD was 8.1 cm/cm(2) (range 7.3-9.4) for 0- to 7-day-old neonates (n = 12), 6.9 cm/cm(2) (range 4.7-8.7) for 8- to 28-day-olds (n = 10), 7.3 cm/cm(2) (range 6.1-8.8) for 1- to 6-month-olds (n = 19) and 6.7 cm/cm(2) (range 6.5-9.2) for 3-year-olds (n = 4). After the first week, there was no significant correlation between age and FCD. Conclusion: FCD of the buccal mucosa decreases after the first week of life. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:73 / 77
页数:5
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