Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing

被引：244

作者：

Naccache, Samia N. ^{[1
,2
]}

Peggs, Karl S. ^{[3
]}

Mattes, Frank M. ^{[4
]}

Phadke, Rahul ^{[5
]}

Garson, Jeremy A. ^{[7
]}

Grant, Paul ^{[4
]}

Samayoa, Erik ^{[1
,2
]}

Federman, Scot ^{[1
,2
]}

Miller, Steve ^{[1
,2
]}

Lunn, Michael P. ^{[6
]}

Gant, Vanya ^{[4
]}

Chiu, Charles Y. ^{[1
,2
,8
]}

机构：

[1] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94107 USA

[2] Univ Calif San Francisco, Abbott Viral Diagnost & Discovery Ctr, San Francisco, CA 94107 USA

[3] Univ Coll London Hosp NHS Fdn Trust, Dept Clin Hematol, London, England

[4] Univ Coll London Hosp NHS Fdn Trust, Dept Clin Microbiol, London, England

[5] Univ Coll London Hosp NHS Fdn Trust, Dept Neuropathol, London, England

[6] Univ Coll London Hosp NHS Fdn Trust, Dept Neurol, London, England

[7] UCL, Div Infect & Immun, Res Dept Infect, London WC1E 6BT, England

[8] Univ Calif San Francisco, Dept Med, Div Infect Dis, San Francisco, CA 94107 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2015年 / 60卷 / 06期

基金：

美国国家卫生研究院;

关键词：

VA/HMO astrovirus clade; encephalitis; deafness; next-generation sequencing; pathogen discovery; CATTLE;

D O I：

10.1093/cid/ciu912

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.

引用

页码：919 / 923

页数：5

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