Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients

被引：18

作者：

Andreadou, Eleni G. ^{[1
,4
]}

Katsipis, Georgios ^{[1
,4
]}

Tsolaki, Magda ^{[2
,3
,4
]}

Pantazaki, Anastasia A. ^{[1
,4
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem, Lab Biochem, Thessaloniki 54124, Greece

[2] Aristotle Univ Thessaloniki, AHEPA Univ Gen Hosp Thessaloniki, Neurol Dept 1, Thessaloniki 54124, Greece

[3] Greek Assoc Alzheimers Dis & Related Disorders GA, Thessaloniki, Greece

[4] Ctr Interdisciplinary Res & Innovat, Lab Neurodegenerat Dis LND, Thessaloniki 57001, Greece

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 357卷

关键词：

Biomarkers; Alzheimer's Disease; Mild Cognitive Impairment; Lipopolysaccharides; Cyclooxygenases; Inflammation; BLOOD-BRAIN-BARRIER; INDUCED-NEUROINFLAMMATION; INFLAMMATORY RESPONSE; CHLAMYDIA-PNEUMONIAE; BINDING PROTEIN; MESSENGER-RNA; AMYLOID-BETA; LPS; EXPRESSION; SERUM;

D O I：

10.1016/j.jneuroim.2021.577561

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study reports elevated levels of bacterial lipopolysaccharides (LPSs) and cyclooxygenases (COX-1/2) in blood serum and cerebrospinal fluid (CSF) of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) patients compared to cognitively healthy individuals, indicating LPSs as promising biomarkers, especially in serum. LPSs, in both fluids, positively correlate with COX-1/2, A beta 42 and tau and negatively with mental state. Furthermore, COX-2 is the main determinant of LPSs presence in serum, whereas COX-1 in CSF. These results underline the significance of microbial/ inflammatory involvement in dementia and offer novel perspectives on the roles of LPSs and COX in pathogenesis of AD.

引用

页数：13

共 115 条

[1] Targeting cyclooxygenases-1 and-2 in neuroinflammation: Therapeutic implications [J].

Aid, Saba ;

Bosetti, Francesca .

BIOCHIMIE, 2011, 93 (01) :46-51

[2] Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD [J].

Al-Obaide, Mohammed A. I. ;

Singh, Ruchi ;

Datta, Palika ;

Rewers-Felkins, Kathy A. ;

Salguero, Maria V. ;

Al-Obaidi, Ibtisam ;

Kottapalli, Kameswara Rao ;

Vasylyeva, Tetyana L. .

JOURNAL OF CLINICAL MEDICINE, 2017, 6 (09)

[3] Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement [J].

Albillos, A ;

de la Hera, A ;

González, M ;

Moya, JL ;

Calleja, JL ;

Monserrat, J ;

Ruiz-del-Arbol, L ;

Alvarez-Mon, M .

HEPATOLOGY, 2003, 37 (01) :208-217

[4] Oxidative Stress Mediated Mitochondrial and Vascular Lesions as Markers in the Pathogenesis of Alzheimer Disease [J].

Aliev, G. ;

Priyadarshini, M. ;

Reddy, V. P. ;

Grieg, N. H. ;

Kaminsky, Y. ;

Cacabelos, R. ;

Ashraf, G. Md ;

Jabir, N. R. ;

Kamal, M. A. ;

Nikolenko, V. N. ;

Zamyatnin, A. A., Jr. ;

Benberin, V. V. ;

Bachurin, S. O. .

CURRENT MEDICINAL CHEMISTRY, 2014, 21 (19) :2208-2217

[5] TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells [J].

Alpizar, Yeranddy A. ;

Boonen, Brett ;

Sanchez, Alicia ;

Jung, Carole ;

Lopez-Requena, Alejandro ;

Naert, Robbe ;

Steelant, Brecht ;

Luyts, Katrien ;

Plata, Cristina ;

De Vooght, Vanessa ;

Vanoirbeek, Jeroen A. J. ;

Meseguer, Victor M. ;

Voets, Thomas ;

Alvarez, Julio L. ;

Hellings, Peter W. ;

Hoet, Peter H. M. ;

Nemery, Benoit ;

Valverde, Miguel A. ;

Talavera, Karel .

NATURE COMMUNICATIONS, 2017, 8

[6] Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration [J].

Alvares Batista, Carla Ribeiro ;

Gomes, Giovanni Freitas ;

Candelario-Jalil, Eduardo ;

Fiebich, Bernd L. ;

Pinheiro de Oliveira, Antonio Carlos .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (09)

[7]

Andreadou E, 2017, J ALZHEIMERS DIS, V59, P209, DOI [10.3233/JAD-161020, 10.3233/jad-161020]

[8]

[Anonymous], 2017, FRONTIERS ANTIINFECT

[9] Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae [J].

Appelt, Denah M. ;

Roupas, Maria R. ;

Way, Deana S. ;

Bell, Marcus G. ;

Albert, Elizabeth V. ;

Hammond, Christine J. ;

Balin, Brian J. .

BMC NEUROSCIENCE, 2008, 9 (1) :13

[10] The Possibility of an Infectious Etiology of Alzheimer Disease [J].

Ashraf, Ghulam M. ;

Tarasov, Vadim V. ;

Makhmutova, Alfiya ;

Chubarev, Vladimir N. ;

Avila-Rodriguez, Marco ;

Bachurin, Sergey O. ;

Aliev, Gjumrakch .

MOLECULAR NEUROBIOLOGY, 2019, 56 (06) :4479-4491

← 1 2 3 4 5 6 7 8 9 10 →