Survival Patterns in White-tailed and Mule Deer after Oral Inoculation with a Standardized, Conspecific Prion Dose

被引：21

作者：

Miller, Michael W. ^{[1
]}

Wolfe, Lisa L. ^{[1
]}

Sirochman, Tracey M. ^{[1
]}

Sirochman, Michael A. ^{[1
]}

Jewell, Jean E. ^{[2
]}

Williams, Elizabeth S. ^{[2
]}

机构：

[1] Wildlife Res Ctr, Colorado Div Wildlife, Ft Collins, CO 80526 USA

[2] Univ Wyoming, Dept Vet Sci, Wyoming State Vet Lab, Laramie, WY 82070 USA

来源：

JOURNAL OF WILDLIFE DISEASES | 2012年 / 48卷 / 02期

关键词：

CHRONIC WASTING DISEASE; PROTEIN; SHEEP; SUSCEPTIBILITY; BLOOD;

D O I：

10.7589/0090-3558-48.2.526

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We orally inoculated white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) with a standardized, conspecific prion dose and collected biologic samples throughout the disease course. Mule deer (PRNP genotype 225SS) and PRNP genotype 96GG white-tailed deer succumbed along similar trajectories, but 96GS- and 96SS-genotype individuals tended to survive longer.

引用

页码：526 / 529

页数：4

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