Limonoids with modified furan rings from root barks of Toona sinensis

被引：22

作者：

Li, Jun-He ^{[1
]}

Li, Yi ^{[2
]}

An, Fa-Liang ^{[1
]}

Zhou, Miao-Miao ^{[1
]}

Luo, Jie ^{[1
]}

Jian, Kai-Li ^{[1
]}

Luo, Jun ^{[1
]}

Kong, Ling Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

[2] Nanjing Normal Univ, Testing & Anal Ctr, Nanjing 210046, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2016年 / 72卷 / 47期

关键词：

Toona sinensis (A. Juss.) Roem; Limonoids; Modified furan rings; Cytotoxicity; anti-Inflammatory activity; TETRANORTRITERPENOID DERIVATIVES; BEARING LIMONOIDS; CHINESE MANGROVE; ANTIFEEDANTS;

D O I：

10.1016/j.tet.2016.09.061

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Toonasinemines A-K (1-12), 12 new azadirone- and gedunin-type limonoids with eight-classes of modified furan rings, were isolated from the root barks of Toona sinensis (A. Juss.) Roem. Their structures were elucidated based on detailed spectroscopic analyses, and the absolute configurations of 1-9 were established by the electronic circular dichroism exciton chirality method. The lactam-bearing moieties in compounds 1-7 were rare in limonoids family. Results of bioactivities screening exhibited that 1, 4, and 8 showed moderate cytotoxicities against HepG2, MCF-7, and U2OS human cancer cell lines, and 1, 2, 6, 8, and 9 exhibited marked inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages at nontoxic concentration. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：7481 / 7487

页数：7

共 21 条

[1] Mechanism of Toona sinensis-stimulated adrenal steroidogenesis in primary rat adrenal cells [J].