Autoimmunity and Graves' Disease

被引：39

作者：

Bahn, R. S. ^{[1
]}

机构：

[1] Mayo Clin, Mayo Clin Sch Med, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 91卷 / 04期

关键词：

D O I：

10.1038/clpt.2012.10

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Current treatment options for Graves hyperthyroidism and the related ophthalmopathy (GO) are not uniformly effective and carry with them potentially serious side effects. As a result, efforts have been focused on the development of novel therapies. Progress has been made, particularly in the production of thyroid-stimulating hormone receptor (TSHR) antagonists, as either monoclonal blocking antibodies or small-molecule ligands. In addition, rituximab (RTX) is the first targeted biological therapy to be studied as treatment for these conditions. © 2012 American Society for Clinical Pharmacology and Therapeutics.

引用

页码：577 / 579

页数：3

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