Management of a Multicomorbid Patient with Heart Failure

被引:3
作者
Magri, Gianluigi [1 ]
Bentivenga, Crescenzio [1 ]
Cosentino, Eugenio Roberto [1 ]
Esposti, Daniela Degli [1 ]
Borghi, Claudio [1 ]
Dormi, Ada [2 ]
机构
[1] Univ Bologna, Med & Surg Sci Dept, Internal Med Unit Dir C Borghi, Bologna, Italy
[2] Univ Bologna, Med & Surg Sci Dept, Med Stat & Clin Epidemiol, Bologna, Italy
关键词
Comorbidity; Sacubitril; Valsartan; Heart failure;
D O I
10.1159/000484888
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The optimal use of sacubitril/valsartan in clinical practice needs further investigation, in particular for patients with multiple comorbidities, as such patients are usually poorly represented in clinical trials. To this end, well-documented case reports may add further evidence to the bulk of "field practice" experience on sacubitril/valsartan. We report here the case of a patient with heart failure with reduced ejection refraction with multiple comorbidities treated with sacubitril/ valsartan. Overall, sacubitril/valsartan led to a prompt (within a few months) improvement in LVEF (+15%, from 38 to 53%), without any noticeable adverse events. This therapy also allowed the patient to discontinue furosemide. (C) 2017 S. Karger AG, Basel
引用
收藏
页码:21 / 23
页数:3
相关论文
共 6 条
[1]  
Callan Paul D, 2016, Clin Med (Lond), V16, ps37
[2]   Practical considerations on the introduction of sacubitril/valsartan in clinical practice: Current evidence and early experience [J].
Farmakis, Dimitrios ;
Bistola, Vassiliki ;
Karavidas, Apostolos ;
Parissis, John .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016, 223 :781-784
[3]   Heart failure trials on pharmacological therapy in 2015: lessons learned and future outlook [J].
Latini, Roberto ;
Masson, Serge ;
Staszewsky, Lidia .
EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2016, 14 (06) :703-711
[4]   Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure [J].
McMurray, John J. V. ;
Packer, Milton ;
Desai, Akshay S. ;
Gong, Jianjian ;
Lefkowitz, Martin P. ;
Rizkala, Adel R. ;
Rouleau, Jean L. ;
Shi, Victor C. ;
Solomon, Scott D. ;
Swedberg, Karl ;
Zile, Michael R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (11) :993-1004
[5]   Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy [J].
Okumura, Naoki ;
Jhund, Pardeep S. ;
Gong, Jianjian ;
Lefkowitz, Martin P. ;
Rizkala, Adel R. ;
Rouleau, Jean L. ;
Shi, Victor C. ;
Swedberg, Karl ;
Zile, Michael R. ;
Solomon, Scott D. ;
Packer, Milton ;
McMurray, John J. V. .
CIRCULATION-HEART FAILURE, 2016, 9 (09)
[6]   2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC [J].
Ponikowski, Piotr ;
Voors, Adriaan A. ;
Anker, Stefan D. ;
Bueno, Hector ;
Cleland, John G. F. ;
Coats, Andrew J. S. ;
Falk, Volkmar ;
Gonzalez-Juanatey, Jose Ramon ;
Harjola, Veli-Pekka ;
Jankowska, Ewa A. ;
Jessup, Mariell ;
Linde, Cecilia ;
Nihoyannopoulos, Petros ;
Parissis, John T. ;
Pieske, Burkert ;
Riley, Jillian P. ;
Rosano, Giuseppe M. C. ;
Ruilope, Luis M. ;
Ruschitzka, Frank ;
Rutten, Frans H. ;
van der Meer, Peter ;
Filippatos, Gerasimos ;
McMurray, John J. V. ;
Aboyans, Victor ;
Achenbach, Stephan ;
Agewall, Stefan ;
Al-Attar, Nawwar ;
Atherton, John James ;
Bauersachs, Johann ;
Camm, A. John ;
Carerj, Scipione ;
Ceconi, Claudio ;
Coca, Antonio ;
Elliott, Perry ;
Erol, Cetin ;
Ezekowitz, Justin ;
Fernandez-Golfin, Covadonga ;
Fitzsimons, Donna ;
Guazzi, Marco .
EUROPEAN JOURNAL OF HEART FAILURE, 2016, 18 (08) :891-975