Calculation of the minimum significant difference at the NOEC using a non-parametric test

被引：16
作者：
van der Hoeven, Nelly [1 ]
机构：
[1] ECOSTAT, NL-2332 AA Leiden, Netherlands
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2008年 / 70卷 / 01期
关键词：
minimum significant difference; wilcoxon test; NOEL; non-parametric test;
D O I：
10.1016/j.ecoenv.2007.06.010
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The minimum significant difference (MSD) at the no observed effect concentration (NOEL) is required in many guidelines for standardised ecotoxicological tests. A method is given to calculate the MSD if non-parametric pair-wise comparison of each concentration with the control is used to determine the NOEC. (C) 2007 Elsevier Inc. All rights reserved.
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收藏
页码：61 / 66
页数：6
相关论文
共 14 条
  • [1] [Anonymous], EPA600491002 ENV MON
  • [2] CHAPMAN PF, 1995, REP WORKSH HELD ROYA
  • [3] A warning: NOECs are inappropriate for regulatory use
    Chapman, PM
    Caldwell, RS
    Chapman, PF
    [J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1996, 15 (02) : 77 - 79
  • [4] NEW TABLES FOR MULTIPLE COMPARISONS WITH CONTROL
    DUNNETT, CW
    [J]. BIOMETRICS, 1964, 20 (03) : 482 - &
  • [5] GULLEY D, 1996, TOXSTAT 3 5
  • [6] Hollander M., 1999, Nonparametric Statistical Methods
  • [7] IVES MA, 1996, TOXCALC 5 0
  • [8] *NELAC, NAT ENV LAB ACCR C 2
  • [9] *OECD, 2003, DRAFT GUID DOC STAT
  • [10] Multiple test procedures for identifying the maximum safe dose
    Tamhane, AC
    Dunnett, CW
    Green, JW
    Wetherington, JD
    [J]. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 2001, 96 (455) : 835 - 843
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