Nevogenesis - New thoughts regarding a classical problem

被引:57
作者
Krengel, S [1 ]
机构
[1] Med Univ Lubeck, Dept Dermatol, D-23538 Lubeck, Germany
关键词
D O I
10.1097/01.dad.0000175532.27368.3f
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The development of melanocytic nevi is a multifactorial and heterogeneous biologic process that involves prenatal and postnatal steps. As a consequence, there are two main perspectives to nevi: that of a hamartoma and that of a benign tumor. In this review, dermatopathological studies on congenital and acquired nevi, including studies on age-related and location-dependent changes, are analyzed. These studies have lead to different hypothetical concepts on the evolution of individual lesions. In the light of findings from experimental embryology and stem cell biology, we discuss the histogenesis of nevi with special reference to the temporospatial sequence of melanocyte-basement membrane interactions and hair follicle genesis. Regarding the mechanisms of postnatal nevus development, epidemiological studies demonstrate the importance of constitutional and environmental influences, especially ultraviolet light. Possible molecular pathways of solar nevogenesis involve ultraviolet-induced alterations of the cellular microenvironment (eg, changes in the expression of cytokines and melanocyte adhesion molecules). Recent results and future directions of clinical and experimental research are presented.
引用
收藏
页码:456 / 465
页数:10
相关论文
共 89 条
[41]   CONGENITAL NEVOCYTIC NEVI AND MALIGNANT MELANOMAS [J].
KOPF, AW ;
BART, RS ;
HENNESSEY, P .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1979, 1 (02) :123-130
[42]   Selective down-regulation of the α6-integrin subunit in melanocytes by UVB light [J].
Krengel, S ;
Stark, I ;
Geuchen, C ;
Knoppe, B ;
Scheel, G ;
Schlenke, P ;
Gebert, A ;
Wünsch, L ;
Brinckmann, J ;
Tronnier, M .
EXPERIMENTAL DERMATOLOGY, 2005, 14 (06) :411-419
[43]   Cadherin expression pattern in melanocytic tumors more likely depends on the melanocyte environment than on tumor cell progression [J].
Krengel, S ;
Grotelüschen, F ;
Bartsch, S ;
Tronnier, M .
JOURNAL OF CUTANEOUS PATHOLOGY, 2004, 31 (01) :1-7
[44]   MMP-2, TIMP-2 and MT1-MMP are differentially expressed in lesional skin of melanocytic nevi and their expression is modulated by UVB-light [J].
Krengel, S ;
Alexander, M ;
Brinckmann, J ;
Tronnier, M .
JOURNAL OF CUTANEOUS PATHOLOGY, 2002, 29 (07) :390-396
[46]  
KUEHNLPETZOLDT C, 1984, AM J DERMATOPATH, V6, P81
[47]  
Laud K, 2003, CANCER RES, V63, P3061
[48]  
LUND HZ, 1949, AM J PATHOL, V25, P1117
[49]   The Eastern Australian Childhood Nevus Study: Site differences in density and size of melanocytic nevi in relation to latitude and phenotype [J].
MacLennan, R ;
Kelly, JW ;
Rivers, JK ;
Harrison, SL .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 48 (03) :367-375
[50]   WHAT ARE NEVUS CELLS [J].
MAGANAGARCIA, M ;
ACKERMAN, AB .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1990, 12 (01) :93-102