Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review

被引：57
作者：
Akiyama, Yoshiyuki [1 ]
Homma, Yukio [1 ,2 ]
Maeda, Daichi [3 ,4 ]
机构：
[1] Univ Tokyo, Dept Urol, Grad Sch Med, Tokyo, Japan
[2] Japanese Red Cross Med Ctr, Tokyo, Japan
[3] Akita Univ, Dept Cellular & Organ Pathol, Grad Sch Med, Akita, Japan
[4] Osaka Univ, Dept Clin Genom, Grad Sch Med, Osaka, Japan
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2019年 / 34卷 / 01期
关键词：
Interstitial cystitis; Bladder pain syndrome; Terminology; B cell; Plasma cell; Mast cell; BLADDER MAST-CELLS; SYNDROME/INTERSTITIAL CYSTITIS; CLINICAL-FEATURES; HUNNER ULCERS; DIAGNOSIS; CLASSIFICATION; EXPRESSION; SEVERITY; LIGHT;
D O I：
10.14670/HH-18-028
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Interstitial cystitis/bladder pain syndrome (IC/BPS) is an umbrella term of chronic debilitating conditions of unknown etiology characterized by symptoms of lower urinary tract hypersensitivity such as bladder pain/discomfort, urgency, and urinary frequency. The pathological features of IC/BPS have been generally reported as non-specific chronic inflammatory changes, with mast cell infiltration as a potential key finding. However, growing evidence reveals a histological distinction between IC/BPS with Hunner lesions and IC/BPS without Hunner lesions, and also sheds doubt on the diagnostic value of the mast cell count. Specifically, IC/BPS with Hunner lesions is an inflammatory disorder characterized by pancystitis with B cell abnormalities and epithelial denudation, while IC/BPS without Hunner lesions shows minimal histological changes. The umbrella term "IC/BPS" connects totally distinct clinical entities. Pathological evaluation thus plays an important role in the precise subtyping and clinical management of IC/BPS. In addition, terminology should be developed to refer separately to IC/BPS with Hunner lesions and IC/BPS without Hunner lesions.
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页码：25 / 32
页数：8
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