Preussins with Inhibition of IL-6 Expression from Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine Sponge Phakellia fusca

被引：22

作者：

Gu, Bin-Bin ^{[1
]}

Jiao, Fu-Rong ^{[1
]}

Wu, Wei ^{[1
]}

Jiao, Wei-hua ^{[1
]}

Li, Lei ^{[1
]}

Sun, Fan ^{[1
]}

Wang, Shu-Ping ^{[1
]}

Yang, Fan ^{[1
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Res Ctr Marine Drugs, State Key Lab Oncogenes & Related Genes, Dept Pharm,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 10期

基金：

国家高技术研究发展计划(863计划);

关键词：

NATURAL-PRODUCTS; STEREOSELECTIVE-SYNTHESIS; ANTIFUNGAL AGENT; (+)-PREUSSIN; CANCER; INTERLEUKIN-6; CONCISE; ANALOGS;

D O I：

10.1021/acs.jnatprod.8b00662

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New pyrrolidine alkaloids, preussins C-I (1-7) and (11R)/(11S)-preussins J and K (8 and 9), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. The structures and configurations of these preussins were elucidated by detailed spectroscopic analysis, modified Mosher's method, and comparisons with literature data. These compounds showed strong to moderate inhibitory activity toward IL-6 production in lipopolysaccharide-induced THP-1 cells with IC50 values ranging from 0.11 to 22 mu M, but were inactive against normal tumor cell lines and fungi.

引用

收藏

页码：2275 / 2281

页数：7

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