Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp SCSIO 01127
被引:71
作者:
Niu, Siwen
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机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Niu, Siwen
[1
,2
]
Li, Sumei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Li, Sumei
[1
]
Chen, Yuchan
论文数: 0引用数: 0
h-index: 0
机构:
Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Chen, Yuchan
[3
]
Tian, Xinpeng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Tian, Xinpeng
[1
]
Zhang, Haibo
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Zhang, Haibo
[1
]
Zhang, Guangtao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Zhang, Guangtao
[1
]
Zhang, Weimin
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h-index: 0
机构:
Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Zhang, Weimin
[3
]
Yang, Xiaohong
论文数: 0引用数: 0
h-index: 0
机构:
Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Yang, Xiaohong
[2
]
Zhang, Si
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Zhang, Si
[1
]
Ju, Jianhua
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Ju, Jianhua
[1
]
Zhang, Changsheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R ChinaChinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
Zhang, Changsheng
[1
]
机构:
[1] Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
[2] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China
[3] Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R China
antimicrobial;
cytotoxicity;
lobophorins;
marine Streptomyces;
South China Sea;
spirotetronate antibiotics;
SP NOV;
PHYSICOCHEMICAL PROPERTIES;
GEN;
NOV;
SEDIMENT;
PRODUCTS;
D O I:
10.1038/ja.2011.78
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
The strain SCSIO 01127, isolated from the South China Sea sediment, was identified as a member of Streptomyces by the 16S rDNA sequence analysis. Two new spirotetronate antibiotics lobophorins E (1) and F (2), along with two known analogs lobophorins A (3) and B (4), were isolated from Streptomyces sp. SCSIO 01127. Their structures were elucidated on the basis of detailed IR, NMR and MS spectroscopic analyses. The new compound lobophorin F (2) showed antibacterial activities against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 with MIC values of 8 mu g ml(-1) for both the strains, better than that of lobophorin B (4). Lobophorin F (2) also displayed better cytotoxic activities than lobophorin B (4), with IC50 of 6.82, 2.93 and 3.16 mu M against SF-268, MCF-7 and NCI-H460, respectively. The Journal of Antibiotics (2011) 64, 711-716; doi:10.1038/ja.2011.78; published online 7 September 2011
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Dai, Huan-Qin
Wang, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
Grad Univ, CAS, Beijing 100049, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Wang, Jian
Xin, Yu-Hua
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Xin, Yu-Hua
Pei, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Grad Univ, CAS, Beijing 100049, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Pei, Gang
Tang, Shu-Kun
论文数: 0引用数: 0
h-index: 0
机构:
Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Peoples R China
Yunnan Univ, Lab Conservat & Utilizat Bioresources, Yunnan Inst Microbiol, Kunming 650091, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Tang, Shu-Kun
Ren, Biao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Grad Univ, CAS, Beijing 100049, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Ren, Biao
论文数: 引用数:
h-index:
机构:
Ward, Alan
Ruan, Ji-Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Ruan, Ji-Sheng
Li, Wen-Jun
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Peoples R China
Yunnan Univ, Lab Conservat & Utilizat Bioresources, Yunnan Inst Microbiol, Kunming 650091, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Li, Wen-Jun
Zhang, Li-Xin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
机构:
Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USAUniv Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
Jiang, ZD
Jensen, PR
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USAUniv Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
Jensen, PR
Fenical, W
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USAUniv Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Dai, Huan-Qin
Wang, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
Grad Univ, CAS, Beijing 100049, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Wang, Jian
Xin, Yu-Hua
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Xin, Yu-Hua
Pei, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Grad Univ, CAS, Beijing 100049, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Pei, Gang
Tang, Shu-Kun
论文数: 0引用数: 0
h-index: 0
机构:
Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Peoples R China
Yunnan Univ, Lab Conservat & Utilizat Bioresources, Yunnan Inst Microbiol, Kunming 650091, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Tang, Shu-Kun
Ren, Biao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Grad Univ, CAS, Beijing 100049, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Ren, Biao
论文数: 引用数:
h-index:
机构:
Ward, Alan
Ruan, Ji-Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Ruan, Ji-Sheng
Li, Wen-Jun
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China
Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Peoples R China
Yunnan Univ, Lab Conservat & Utilizat Bioresources, Yunnan Inst Microbiol, Kunming 650091, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Li, Wen-Jun
Zhang, Li-Xin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R ChinaChinese Acad Sci, Inst Microbiol, Beijing 100190, Peoples R China
机构:
Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USAUniv Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
Jiang, ZD
Jensen, PR
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USAUniv Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
Jensen, PR
Fenical, W
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USAUniv Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA