Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp SCSIO 01127

被引:71
作者
Niu, Siwen [1 ,2 ]
Li, Sumei [1 ]
Chen, Yuchan [3 ]
Tian, Xinpeng [1 ]
Zhang, Haibo [1 ]
Zhang, Guangtao [1 ]
Zhang, Weimin [3 ]
Yang, Xiaohong [2 ]
Zhang, Si [1 ]
Ju, Jianhua [1 ]
Zhang, Changsheng [1 ]
机构
[1] Chinese Acad Sci, S China Sea Inst Oceanol, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
[2] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China
[3] Guangdong Inst Microbiol, Guangzhou, Guangdong, Peoples R China
基金
美国国家科学基金会;
关键词
antimicrobial; cytotoxicity; lobophorins; marine Streptomyces; South China Sea; spirotetronate antibiotics; SP NOV; PHYSICOCHEMICAL PROPERTIES; GEN; NOV; SEDIMENT; PRODUCTS;
D O I
10.1038/ja.2011.78
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The strain SCSIO 01127, isolated from the South China Sea sediment, was identified as a member of Streptomyces by the 16S rDNA sequence analysis. Two new spirotetronate antibiotics lobophorins E (1) and F (2), along with two known analogs lobophorins A (3) and B (4), were isolated from Streptomyces sp. SCSIO 01127. Their structures were elucidated on the basis of detailed IR, NMR and MS spectroscopic analyses. The new compound lobophorin F (2) showed antibacterial activities against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 with MIC values of 8 mu g ml(-1) for both the strains, better than that of lobophorin B (4). Lobophorin F (2) also displayed better cytotoxic activities than lobophorin B (4), with IC50 of 6.82, 2.93 and 3.16 mu M against SF-268, MCF-7 and NCI-H460, respectively. The Journal of Antibiotics (2011) 64, 711-716; doi:10.1038/ja.2011.78; published online 7 September 2011
引用
收藏
页码:711 / 716
页数:6
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