ESCRT-dependent cargo sorting at multivesicular endosomes

被引：116
作者：
Frankel, E. B. [1 ]
Audhya, Anjon [1 ]
机构：
[1] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Biomol Chem, 440 Henry Mall, Madison, WI 53706 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2018年 / 74卷
关键词：
ESCRT machinery; Multivesicular endosome; Cargo sorting; Intralumenal vesicle; Ubiquitin; EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR; UBIQUITINATED PROTEINS; EGF RECEPTOR; INWARD VESICULATION; PLASMA-MEMBRANE; BODY FORMATION; III FILAMENTS; GLUE DOMAIN; RING FINGER;
D O I：
10.1016/j.semcdb.2017.08.020
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The endosomal sorting complex required for transport (ESCRT) machinery is composed of five multi-subunit protein complexes, which act cooperatively at specialized endosomes to facilitate the movement of specific cargoes from the limiting membrane into vesicles that bud into the endosome lumen. Over the past decade, numerous proteins, lipids, and RNAs have been shown to be incorporated into intralumenal vesicles (ILVs), but the mechanisms by which these unique cargoes are captured are only now becoming better understood. Here, we discuss the potential roles that the ESCRT machinery plays during cargo sorting at multivesicular endosomes (MVEs). (c) 2017 Elsevier Ltd. All rights reserved.
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收藏
页码：4 / 10
页数：7
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