Adherence properties of Helicobacter pylori:: Impact on pathogenesis and adaptation to the host

被引：82

作者：

Odenbreit, S ^{[1
]}

机构：

[1] Univ Munich, Max Von Pettenkofer Inst Hyg & Med Microbiol, D-80336 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2005年 / 295卷 / 05期

关键词：

Helicobacter pylori; adherence; colonization; Lewis blood group antigens; outer membrane proteins;

D O I：

10.1016/j.ijmm.2005.06.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The adherence of the human gastric pathogen Helicobacter pylori to the gastric mucosa is widely assumed to play a substantial role in initial colonization and long-term persistence in the human stomach. In the past, a couple of putative adhesins were identified, most of which were members of the large outer membrane protein (OMP) family of H. pylori. Among these, the BabA protein was shown to recognize the Le(b) antigen, which is presented as a dominant surface structure in the gastric mucosa. The SabA adhesin binds to sialylated antigens, which are up-regulated in inflamed gastric tissue. Other OMPs, such as AlpAB or HopZ were also shown to be involved in binding to gastric epithelial cells, but the corresponding receptors are unknown. The aim of this review is to summarize recent data giving new insights in binding specificities of H. pylori adhesins and their role in pathogenesis and adaptation to the host. (c) 2005 Elsevier GmbH. All rights reserved.

引用

页码：317 / 324

页数：8

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