Small molecules with big effects: The role of the microRNAome in cancer and carcinogenesis

被引：87

作者：

Koturbash, Igor ^{[1
]}

Zemp, Franz J. ^{[1
]}

Pogribny, Igor ^{[2
]}

Kovalchuk, Olga ^{[1
]}

机构：

[1] Univ Lethbridge, Dept Biol Sci, Lethbridge, AB T1K 3M4, Canada

[2] Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2011年 / 722卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

MicroRNA; Cancer; Carcinogenesis; Genome instability; ACUTE MYELOID-LEUKEMIA; REAL-TIME PCR; BREAST-CANCER; DOWN-REGULATION; LUNG-CANCER; SMALL RNAS; STEM-CELL; EXPRESSION PROFILES; PROSTATE-CANCER; GENE-EXPRESSION;

D O I：

10.1016/j.mrgentox.2010.05.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Small non-coding RNAs-microRNAs, are potent negative regulators of gene expression. MicroRNAs are involved in multiple biological processes, metabolic regulation, including cell proliferation, differentiation, and programmed cell death. Since the dysregulation of these processes is a hallmark of cancer, microRNAs can be viewed as major contributors to the pathogenesis of cancer, including initiation and progression of cancer. This review focuses on microRNA biogenesis and function, and their role in cancer, metastasis, drug resistance, and tumorigenesis. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：94 / 105

页数：12

共 190 条

[1] Downregulation of microRNAs-143 and-145 in B-cell malignancies [J].

Akao, Yukihiro ;

Nakagawa, Yoshihito ;

Kitade, Yukio ;

Kinoshita, Tomohiro ;

Naoe, Tomoki .

CANCER SCIENCE, 2007, 98 (12) :1914-1920

[2] MicroRNA-143 and-145 in colon cancer [J].

Akao, Yukihiro ;

Nakagawa, Yoshihito ;

Naoe, Tomoki .

DNA AND CELL BIOLOGY, 2007, 26 (05) :311-320

[3] Therapeutic implications of cancer stem cells [J].

Al-Hajj, M ;

Becker, MW ;

Wichal, M ;

Weissman, I ;

Clarke, MF .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (01) :43-47

[4] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[5] Genomic profiling of MicroRNA and messenger RNA reveals deregulated MicroRNA expression in prostate cancer [J].

Ambs, Stefan ;

Prueitt, Robyn L. ;

Yi, Ming ;

Hudson, Robert S. ;

Howe, Tiffany M. ;

Petrocca, Fabio ;

Wallace, Tiffany A. ;

Liu, Chang-Gong ;

Volinia, Stefano ;

Calin, George A. ;

Yfantis, Harris G. ;

Stephens, Robert M. ;

Croce, Carlo M. .

CANCER RESEARCH, 2008, 68 (15) :6162-6170

[6] Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues [J].

Bandres, E. ;

Cubedo, E. ;

Agirre, X. ;

Malumbres, R. ;

Zarate, R. ;

Ramirez, N. ;

Abajo, A. ;

Navarro, A. ;

Moreno, I. ;

Monzo, M. ;

Garcia-Foncillas, J. .

MOLECULAR CANCER, 2006, 5 (1)

[7] The microRNA.org resource: targets and expression [J].

Betel, Doron ;

Wilson, Manda ;

Gabow, Aaron ;

Marks, Debora S. ;

Sander, Chris .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D149-D153

[8] MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis [J].

Bloomston, Mark ;

Frankel, Wendy L. ;

Petrocca, Fabio ;

Volinia, Stefano ;

Alder, Hansjuerg ;

Hagan, John P. ;

Liu, Chang-Gong ;

Bhatt, Darshna ;

Taccioli, Cristian ;

Croce, Carlo M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (17) :1901-1908

[9] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[10] miR-15a and miR-16-1 down-regulation in pituitary adenomas [J].

Bottoni, A ;

Piccin, D ;

Tagliati, F ;

Luchin, A ;

Zatelli, MC ;

Uberti, ECD .

JOURNAL OF CELLULAR PHYSIOLOGY, 2005, 204 (01) :280-285

← 1 2 3 4 5 6 7 8 9 10 →