Effect of Ozonation on the Estrogenicity and Androgenicity of Oil Sands Process-Affected Water

被引:73
作者
He, Yuhe [1 ]
Wiseman, Steve B. [1 ]
Hecker, Markus [1 ,2 ]
Zhang, Xiaowei [3 ,4 ]
Wang, Nan [5 ]
Perez, Leonidas A. [6 ]
Jones, Paul D. [1 ,2 ]
El-Din, Mohamed Gamal [5 ]
Martin, Jonathan W. [6 ]
Giesy, John P. [1 ,3 ,4 ,7 ,8 ,9 ,10 ,11 ]
机构
[1] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada
[2] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5C8, Canada
[3] Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210008, Peoples R China
[4] Nanjing Univ, Sch Environm, Nanjing 210008, Peoples R China
[5] Univ Alberta, Dept Civil & Environm Engn, Edmonton, AB, Canada
[6] Univ Alberta, Dept Lab Med & Pathol, Div Analyt & Environm Chem, Edmonton, AB, Canada
[7] Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada
[8] Michigan State Univ, Dept Zool, Ctr Integrat Toxicol, E Lansing, MI 48824 USA
[9] King Saud Univ, Coll Med, Dept Zool, Riyadh 11461, Saudi Arabia
[10] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
[11] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China
基金
加拿大创新基金会;
关键词
ENDOCRINE-DISRUPTING CHEMICALS; NAPHTHENIC ACIDS; AQUATIC RECLAMATION; RECEPTOR AGONISTS; STABLY EXPRESSES; CELL-LINE; BIODEGRADATION; DEGRADATION; ATHABASCA; TOXICITY;
D O I
10.1021/es2008215
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
There is increasing environmental concern about the volume of oil sands process-affected water (OSPW) produced by the oil sands industry in Alberta, Canada. There is limited knowledge of the toxic effects of OSPW and one of the primary organic constituents, naphthenic acids (NAs), which are thought to be one of the toxic constituents of OSPW. OSPW and NAs can have endocrine disrupting potential. The NAs in OSPW are persistent, but ozonation can significantly reduce concentrations of NA, while increasing their biodegradability, and consequently reduce OSPW toxicity. However, it is of concern that OSPW ozonation might generate hydroxylated cycloaliphatics with endocrine disrupting potential. In this study, the estrogen receptor- (ER) and androgen receptor- (AR) mediated effects of OSPW and ozone-treated OSPW were investigated in vitro by use of T47D-kbluc (estrogen responsive) and MDA-kb2 (androgen responsive) cells. Ozonation neither attenuated nor intensified the estrogenicity of OSPW. The estrogenic responses to untreated OSPW and ozone treated OSPW were 2.58(+/- 0.22)-fold and 2.48(+/- 0.13)-fold greater than those of controls, respectively. Exposure to untreated OSPW produced significant antiandrogenicity in the presence of 0.01, 0.05, or 0.1 nM testosterone (T), while ozone-treated OSPW produced significant antiandrogenicity in the presence of 0.01 or 0.05 nM T. Exposure to untreated and ozone-treated OSPW also caused potentiation of androgen receptor-mediated effects of T. OSPW could cause estrogenic and antiandrogenic effects through receptor mediated pathways, and ozonation can partially mitigate the OSPW antiandrogenicity as well as androgen potentiating effect, without increasing estrogen potency.
引用
收藏
页码:6268 / 6274
页数:7
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