Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis

被引：35
|
作者：
Hegardt, FG [1 ]
机构：
[1] Univ Barcelona, Sch Pharm, Dept Biochem & Mol Biol, Div 4, E-08028 Barcelona, Spain
来源：
BIOCHIMIE | 1998年 / 80卷 / 10期
关键词：
ketogenesis; mitochondrial HMG-CoA synthase; PPAR; COUP-TF; HNF-4; transcriptional regulation;
D O I：
10.1016/S0300-9084(00)88874-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondrial and cytosolic HMG-CoA synthases are encoded by two different genes. Control of ketogenesis is exerted by transcriptional regulation of mitochondrial HMG-CoA synthase. Fasting, cAMP, and fatty acids increase its transcriptional rate, while refeeding and insulin repress it. Fatty acids increase transcription through peroxisomal proliferator regulatory element (PPRE), to which peroxisome proliferator activated receptor (PPAR) can bind. Other transcription factors such as chicken ovalbumin upstream promoter transcription factor (COUP-TF) and hepatocyte nuclear factor 4 (HNF-4) compete for the PPRE site, modulating the response of PPAR. (C) Societe francaise de biochimie et biologie moleculaire / Elsevier, Paris.
引用
收藏
页码：803 / 806
页数：4
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