COVID-19 Vaccine Effectiveness against Omicron Variant among Underage Subjects: The Veneto Region's Experience

被引:7
作者
Cocchio, Silvia [1 ]
Zabeo, Federico [1 ]
Tremolada, Giulia [1 ]
Facchin, Giacomo [1 ]
Venturato, Giovanni [1 ]
Marcon, Thomas [2 ]
Saia, Mario [2 ]
Tonon, Michele [3 ]
Mongillo, Michele [3 ]
Da Re, Filippo [3 ]
Russo, Francesca [3 ]
Baldo, Vincenzo [1 ]
机构
[1] Univ Padua, Dept Cardiac Thorac & Vasc Sci & Publ Hlth, I-35131 Padua, Italy
[2] Azienda Zero, I-35100 Padua, Italy
[3] Reg Directorate Prevent Food Safety Vet Publ Hlth, I-30123 Venice, Italy
关键词
SARS-CoV-2; COVID-19; age-group of children; age-group of adolescents; VOCs; Delta; Omicron; vaccines; vaccine effectiveness; public health; SARS-COV-2; INFECTION;
D O I
10.3390/vaccines10081362
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Even if most of the complications due to COVID-19 are observed in the elderly, in Italy the impact of COVID-19 among young people has not been negligible. Furthermore, their contribution to SARS-CoV-2 circulation is still unclear. These reasons have driven policy makers to involve subjects aged 5 to 17 years in the COVID-19 vaccination campaign. However, the trade-off of vaccinating this age-group should be further investigated, especially in view of the rise of new immunologically evasive variants of concern (VOCs). We used regional databases to retrospectively estimate vaccine effectiveness over time of each approved vaccination schedule among children (5-11) and adolescents (12-17). Our findings suggest that COVID-19 vaccines were highly effective and their protection levels lasted longer during a period of Delta variant predominance, whereas they offered just mild to moderate levels of protection-apparently affected by a rapid waning effect-in a period of Omicron variant predominance. Considering these results, it is plausible to evaluate a reformulation of possible future COVID-19 vaccination campaigns among underage subjects. However, effectiveness against serious complications due to COVID-19, as well as indirect benefits of underage vaccinations, should first be addressed. Furthermore, vaccine effectiveness should be kept monitored, as new VOCs may arise, but also new adapted vaccines may start being administered.
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页数:14
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