Activation-induced cytidine deaminase structure and functions: A species comparative view

被引：31
|
作者：
Barreto, Vasco M. [1 ]
Magor, Brad G. [2 ]
机构：
[1] Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal
[2] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E5, Canada
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2011年 / 35卷 / 09期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Activation-induced cytidine deaminase; AID; Immunoglobulin; Somatic hypermutation; Class switch recombination; Evolution; Review; CLASS-SWITCH RECOMBINATION; IMMUNOGLOBULIN HEAVY-CHAIN; DNA-POLYMERASE-ETA; SINGLE-STRANDED-DNA; PROTEIN-KINASE-A; VARIABLE LYMPHOCYTE RECEPTORS; SOMATIC HYPERMUTATION; B-CELL; ANTIBODY DIVERSIFICATION; GENE CONVERSION;
D O I：
10.1016/j.dci.2011.02.005
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
In the ten years since the discovery of activation-induced cytidine deaminase (AID) there has been considerable effort to understand the mechanisms behind this enzyme's ability to target and modify immunoglobulin genes leading to somatic hypermutation and class switch recombination. While the majority of research has focused on mouse and human models of AID function, work on other species, from lamprey to rabbit and sheep, has taught us much about the scope of functions of the AID mutator. This review takes a species-comparative approach to what has been learned about the AID mutator enzyme and its role in humoral immunity. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：991 / 1007
页数：17
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