CaRe high - Cascade screening and registry for high cholesterol in Germany

被引：10

作者：

Schmidt, Nina ^{[1
]}

Grammer, Tanja ^{[2
]}

Gouni-Berthold, Ioanna ^{[3
]}

Julius, Ulrich ^{[4
]}

Kassner, Ursula ^{[5
]}

Klose, Gerald ^{[6
]}

Koenig, Christel ^{[7
]}

Laufs, Ulrich ^{[8
]}

Otte, Britta ^{[9
]}

Steinhagen-Thiessen, Elisabeth ^{[5
]}

Wanner, Christoph ^{[10
,11
]}

Maerz, Winfried ^{[1
,12
,13
,14
,15
]}

机构：

[1] DACH Gesell Pravent Herz Kreislauf Erkrankunge eV, Hamburg, Germany

[2] Heidelberg Univ, Mannheim Med Fac, Mannheimer Inst Publ Hlth, Heidelberg, Germany

[3] Univ Cologne, Ctr Endocrinol Diabet & Prevent Med, Cologne, Germany

[4] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, Dresden, Germany

[5] Charite, Lipid Clin, Ctr Internal Med Gastroenterol & Nephrol, Berlin, Germany

[6] Joint Practice Internal Med Gastroenterol & Cardi, Bremen, Germany

[7] Klinikum Links Weser, Lipid Clin, Clin Internal Med, Bremen, Germany

[8] Univ Saarland, Clin Internal Med Cardiol Angiol & Med Intens Car, Homburg, Germany

[9] Univ Hosp Munster, Lipid Clin, Med Clin D, Munster, Germany

[10] Univ Hosp Wurzburg, Dept Internal Med 1, Wurzburg, Germany

[11] Univ Hosp Wurzburg, CHFC, Wurzburg, Germany

[12] Synlab Holding Germany GmbH, Synlab Acad, Mannheim, Germany

[13] Med Univ Graz, Clin Inst Med, Graz, Austria

[14] Med Univ Graz, Chem Lab Diagnost, Graz, Austria

[15] Heidelberg Univ, Mannheim Med Fac, Med Clin 5, Nephrol,Hypertens,Rheumatol,Endocrinol, Mannheim, Germany

来源：

ATHEROSCLEROSIS SUPPLEMENTS | 2017年 / 30卷

关键词：

Familial hypercholesterolemia; Cascade screening; Patient registry; Cardiovascular disease; ASSOCIATION EXPERT PANEL; PATIENTS CLINICAL GUIDANCE; FAMILIAL HYPERCHOLESTEROLEMIA; HEART-DISEASE; RECEPTOR; DIAGNOSIS; PATHOGENESIS; PREVALENCE; MANAGEMENT; MUTATIONS;

D O I：

10.1016/j.atherosclerosissup.2017.05.015

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Introduction: Familial hypercholesterolemia (FH) is an inherited disorder of the LDL metabolism, leading to cardiovascular disease, even at young age. This risk can be significantly lowered by early diagnosis and treatment. About 270,000 patients affected in Germany are not diagnosed correctly and only a small number is treated properly. To improve FH diagnosis in the general population a cascade screening and registry data is warranted, yet missing in Germany. This project aims to fill this gap. Methods: Study assistants approach physicians and lipid clinics to introduce the cascade screening and registry. The physicians identify potential FH patients and include them in the study. Patient data is acquired via questionnaires about medical history. Patients meeting at least two inclusion criteria (LDL-C > 190 mg/dl or total cholesterol > 290 mg/dl; tendon xanthomas; family history of hypercholesterolemia or early myocardial infarction) are included in the registry. Family members will be contacted and physicians get feedback about diagnosis and treatment options. Ethical approvals for all German states have been collected. Results: So far physicians, lipid clinics and patients within the Rhein-Neckar region, the Saarland, North-Rhine-Westphalia, Upper Bavaria, Bremen, Saxonia and Berlin have joined the study. We expect to include more than 3000 patients during the next two years. Conclusion: After initial patient and data collection the project aims to improve FH-diagnosis and treatment. Utilizing registry data might advance diagnostic criteria and improve detection of FH and thus prevent CVD in this population. (C) 2017 Published by Elsevier Ireland Ltd.

引用

页码：72 / 76

页数：5

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