A mid-life crisis for aging theory

被引：13

作者：

Garber, Ken

机构：

来源：

NATURE BIOTECHNOLOGY | 2008年 / 26卷 / 04期

关键词：

D O I：

10.1038/nbt0408-371

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

From yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs, but the sirtuin hypothesis is now coming under fire. The lifespan was dramatically extended in yeast bearing an extra copy of a sirtuin, the conserved enzyme class. Sirtuins have been shown to extend lifespan in many other organisms, but a schism in the field has erupted over the role that these proteins play in the aging process. Sirtuins are responsible for the health, and longevity, enhancing effects of calorie restriction, a treatment that extends healthy lifespan 40% or more in many organisms, including mice and rats. Drugs such as resveratrol and the antidiabetic drug, SRT501 could treat diseases related to aging.

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页码：371 / 374

页数：4

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